1R1R
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RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-07-15
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
1RLR
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STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1
Descriptor:RIBONUCLEOTIDE REDUCTASE PROTEIN R1
Authors:Uhlin, U., Eklund, H.
Deposit date:1994-08-12
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of ribonucleotide reductase protein R1.
Nature, 370, 1994
1ZYZ
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STRUCTURES OF YEAST RIBONUCLOETIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, GLYCINE
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-13
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZZD
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, Ribonucleoside-diphosphate reductase small chain 2
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-13
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVS
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVT
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVU
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVV
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVW
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVX
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVY
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, 9-per peptide from Ribonucleoside-diphosphate reductase small chain 1, MAGNESIUM ION, ...
Authors:Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J., Dealwis, C.
Deposit date:2005-06-14
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2EUD
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STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I COMPLEXED WITH LIGANDS AND SUBUNIT PEPTIDES
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Dealwis, C., Xu, H., Faber, C., Uchiki, T., Fairman, J.W., Racca, J.
Deposit date:2005-10-28
Release date:2006-03-07
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2R1R
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RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-07-21
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
2X0X
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RIBONUCLEOTIDE REDUCTASE R1 SUBUNIT OF E. COLI TO 2.3 A RESOLUTION
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA, SULFATE ION
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2009-12-18
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAK
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RIBONUCLEOTIDE REDUCTASE Y730NO2Y MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-03-31
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAP
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RIBONUCLEOTIDE REDUCTASE Y731NO2Y MODIFIED R1 SUBUNIT OF E. COLI TO 2. 1 A RESOLUTION
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-03-31
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAV
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RIBONUCLEOTIDE REDUCTASE Y731NO2Y AND Y730F MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-03-31
Release date:2010-04-14
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAW
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RIBONUCLEOTIDE REDUCTASE Y730NO2Y AND Y731F MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-03-31
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAX
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RIBONUCLEOTIDE REDUCTASE Y730NO2Y AND Y731A MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-04-01
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAY
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RIBONUCLEOTIDE REDUCTASE Y730NO2Y AND C439A MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-04-01
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XAZ
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RIBONUCLEOTIDE REDUCTASE Y730NO2Y AND C439S MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Yokoyama, K., Uhlin, U., Stubbe, J.
Deposit date:2010-04-01
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
J.Am.Chem.Soc., 132, 2010
2XO4
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RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Minnihan, E.C., Seyedsayamdost, M.R., Uhlin, U., Stubbe, J.
Deposit date:2010-08-09
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases.
J.Am.Chem.Soc., 133, 2011
2XO5
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RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Minnihan, E.C., Seyedsayamdost, M.R., Uhlin, U., Stubbe, J.
Deposit date:2010-08-09
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases.
J.Am.Chem.Soc., 133, 2011
2ZLF
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THE STRUCTURAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, FTLDADF
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
2ZLG
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THE STRUCTUAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
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