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6XMA
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BU of 6xma by Molmil
Crystal structure of iron-bound LSD4 from Sphingobium sp. strain SYK-6
Descriptor: Dioxygenase, FE (III) ION, SULFATE ION
Authors:Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D.
Deposit date:2020-06-29
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6.
J.Biol.Chem., 296, 2021
6XM7
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BU of 6xm7 by Molmil
Crystal structure of DCA-S bound to Co-LSD4 from Sphingobium sp. strain SYK-6
Descriptor: (2E)-3-{4-hydroxy-3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-5-methoxyphenyl}prop-2-enoic acid, COBALT (II) ION, DIMETHYL SULFOXIDE, ...
Authors:Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D.
Deposit date:2020-06-29
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6.
J.Biol.Chem., 296, 2021
6XM6
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BU of 6xm6 by Molmil
Crystal structure of cobalt-bound LSD4 from Sphingobium sp. strain SYK-6
Descriptor: COBALT (II) ION, Dioxygenase
Authors:Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D.
Deposit date:2020-06-29
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6.
J.Biol.Chem., 296, 2021
5J53
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BU of 5j53 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
Descriptor: Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ...
Authors:McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
Deposit date:2016-04-01
Release date:2016-11-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6XM9
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BU of 6xm9 by Molmil
Crystal structure of vanillin bound to Co-LSD4 from Sphingobium sp. strain SYK-6
Descriptor: 4-hydroxy-3-methoxybenzaldehyde, ACETATE ION, COBALT (II) ION, ...
Authors:Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D.
Deposit date:2020-06-29
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6.
J.Biol.Chem., 296, 2021
5J55
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BU of 5j55 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
Descriptor: 4-hydroxy-3-methoxybenzaldehyde, Carotenoid oxygenase, FE (III) ION, ...
Authors:McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
Deposit date:2016-04-01
Release date:2016-11-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
7WH0
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BU of 7wh0 by Molmil
structure of C elegans BCMO-1
Descriptor: Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ...
Authors:Pan, W, Liu, L.
Deposit date:2021-12-29
Release date:2022-02-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans .
Front Mol Biosci, 9, 2022
4RSC
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BU of 4rsc by Molmil
Crystal structure of RPE65 in complex with emixustat and palmitate
Descriptor: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D, Shi, W, Palczewski, K.
Deposit date:2014-11-07
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
5U97
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BU of 5u97 by Molmil
Crystal structure of Co-CAO1 in complex with piceatannol
Descriptor: BENZOIC ACID, COBALT (II) ION, Carotenoid oxygenase 1, ...
Authors:Sui, X, Palczewski, K, Banerjee, S, Kiser, P.D.
Deposit date:2016-12-15
Release date:2017-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.
Biochemistry, 56, 2017
6XM8
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BU of 6xm8 by Molmil
Crystal structure of lignostilbene bound to Co-LSD4 from Sphingobium sp. strain SYK-6
Descriptor: COBALT (II) ION, DIMETHYL SULFOXIDE, Dioxygenase, ...
Authors:Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D.
Deposit date:2020-06-29
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6.
J.Biol.Chem., 296, 2021
5J54
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BU of 5j54 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
Descriptor: Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ...
Authors:McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
Deposit date:2016-04-01
Release date:2016-11-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
7T8P
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BU of 7t8p by Molmil
CRYSTAL STRUCTURE OF T151V CAO1
Descriptor: CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION
Authors:Daruwalla, A, Kiser, P.D.
Deposit date:2021-12-16
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CRYSTAL STRUCTURE OF T151V CAO1
To Be Published
5U90
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BU of 5u90 by Molmil
Crystal structure of Co-CAO1 in complex with resveratrol
Descriptor: COBALT (II) ION, Carotenoid oxygenase 1, DIMETHYL SULFOXIDE, ...
Authors:Sui, X, Palczewski, k, Banerjee, S, Kiser, P.D.
Deposit date:2016-12-15
Release date:2017-05-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.
Biochemistry, 56, 2017
7L0E
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BU of 7l0e by Molmil
Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate
Descriptor: (1R)-3-amino-1-{3-[(4,4-difluorocyclohexyl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D.
Deposit date:2020-12-11
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
J.Med.Chem., 64, 2021
3KVC
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BU of 3kvc by Molmil
Crystal structure of bovine RPE65 at 1.9 angstrom resolution
Descriptor: FE (II) ION, Retinoid isomerohydrolase
Authors:Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K.
Deposit date:2009-11-29
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J.Biol.Chem., 285, 2010
7WH1
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BU of 7wh1 by Molmil
structure of C elegans BCMO-2
Descriptor: Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ...
Authors:Pan, W, Liu, L.
Deposit date:2021-12-29
Release date:2022-02-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans .
Front Mol Biosci, 9, 2022
5U8Z
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BU of 5u8z by Molmil
Structure of Fe-CAO1 in complex with beta-fluororesveratrol
Descriptor: 5-[(Z)-2-fluoro-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, CHLORIDE ION, Carotenoid oxygenase 1, ...
Authors:Sui, X, Palczewski, K, Kiser, P.D.
Deposit date:2016-12-15
Release date:2017-05-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.
Biochemistry, 56, 2017
8FTY
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BU of 8fty by Molmil
Crystal structure of the carotenoid isomerooxygenase, NinaB
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, CHLORIDE ION, ...
Authors:Kiser, P.D, Solano, Y.J.
Deposit date:2023-01-14
Release date:2024-01-17
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.
Nat.Chem.Biol., 20, 2024
7K8G
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BU of 7k8g by Molmil
Crystal structure of bovine RPE65 in complex with 4-fluoro-MB-004 and palmitate
Descriptor: (1R)-3-amino-1-{4-fluoro-3-[(2-propylpentyl)oxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D.
Deposit date:2020-09-27
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
J.Med.Chem., 64, 2021
4RYX
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BU of 4ryx by Molmil
Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form
Descriptor: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, (4S)-2-METHYL-2,4-PENTANEDIOL, FE (II) ION, ...
Authors:Kiser, P.D, Palczewski, K.
Deposit date:2014-12-17
Release date:2015-05-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
4OU9
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BU of 4ou9 by Molmil
Crystal structure of apocarotenoid oxygenase in the presence of Triton X-100
Descriptor: Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION
Authors:Sui, X, Palczewski, K, Kiser, P.D.
Deposit date:2014-02-15
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO).
J.Biol.Chem., 289, 2014
8SRL
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BU of 8srl by Molmil
Crystal structure of T151V CAO1 in complex with piceatannol
Descriptor: BENZOIC ACID, Carotenoid oxygenase, FE (II) ION, ...
Authors:Kiser, P.D.
Deposit date:2023-05-05
Release date:2024-05-15
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of CAO1
To Be Published
4ZHK
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BU of 4zhk by Molmil
Crystal structure of RPE65 in complex with MB-002
Descriptor: (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ...
Authors:Kiser, P.D, Palczewski, K.
Deposit date:2015-04-25
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
8DOC
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BU of 8doc by Molmil
Crystal structure of RPE65 in complex with compound 16e and palmitate
Descriptor: (1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, FE (II) ION, ...
Authors:Bassetto, M, Kiser, P.D.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.
J.Med.Chem., 66, 2023
5ULG
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BU of 5ulg by Molmil
Crystal structure of RPE65 in complex with MB-008 and palmitate
Descriptor: (3S)-3-({3-[(1R)-3-amino-1-hydroxypropyl]phenoxy}methyl)hexan-1-ol, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D, Palczewski, K.
Deposit date:2017-01-24
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
J. Pharmacol. Exp. Ther., 362, 2017

 

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