7L0E
Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate
Summary for 7L0E
Entry DOI | 10.2210/pdb7l0e/pdb |
Descriptor | Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (6 entities in total) |
Functional Keywords | non-heme iron, beta propeller, isomerohydrolase, isomerase, monotopic membrane protein, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Bos taurus (Bovine) |
Total number of polymer chains | 2 |
Total formula weight | 123398.61 |
Authors | Kiser, P.D. (deposition date: 2020-12-11, release date: 2021-06-02, Last modification date: 2023-10-18) |
Primary citation | Blum, E.,Zhang, J.,Zaluski, J.,Einstein, D.E.,Korshin, E.E.,Kubas, A.,Gruzman, A.,Tochtrop, G.P.,Kiser, P.D.,Palczewski, K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64:8287-8302, 2021 Cited by PubMed: 34081480DOI: 10.1021/acs.jmedchem.1c00279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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