7L0E
Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Retinoid isomerohydrolase | polymer | 533 | 61040.2 | 2 | UniProt (Q28175) Pfam (PF03055) | Bos taurus (Bovine) | All-trans-retinyl-palmitate hydrolase,Retinal pigment epithelium-specific 65 kDa protein,Retinol isomerase |
| 2 | C, G (A, B) | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) | |||
| 3 | D, H (A, B) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
| 4 | E, I (A, B) | (1R)-3-amino-1-{3-[(4,4-difluorocyclohexyl)methoxy]phenyl}propan-1-ol | non-polymer | 299.4 | 2 | Chemie (XQ7) | |||
| 5 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 844 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 533 (UniProt: Q28175)
| PDB | External Database | Details |
|---|---|---|
| Leu 341 | Ser 341 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122080.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1318.2 | |
| All* | Total formula weight | 123398.6 |
