1JVS
  • Download 1jvs
  • View 1jvs
Molmil generated image of 1jvs
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; A TARGET ENZYME FOR ANTIMALARIAL DRUGS
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Yajima, S., Nonaka, T., Kuzuyama, T., Seto, H., Ohsawa, K.
Deposit date:2001-08-31
Release date:2002-10-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding.
J.Biochem.(Tokyo), 131, 2002
1K5H
  • Download 1k5h
  • View 1k5h
Molmil generated image of 1k5h
1-DEOXY-D-XYLULOSE-5-PHOSPHATE REDUCTOISOMERASE
Descriptor:1-deoxy-D-xylulose-5-phosphate reductoisomerase
Authors:Reuter, K., Sanderbrand, S., Jomaa, H., Wiesner, J., Steinbrecher, I., Beck, E., Hintz, M., Klebe, G., Stubbs, M.T.
Deposit date:2001-10-10
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.
J.Biol.Chem., 277, 2002
1ONN
  • Download 1onn
  • View 1onn
Molmil generated image of 1onn
ISPC APO STRUCTURE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase
Authors:Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F.
Deposit date:2003-02-28
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1ONO
  • Download 1ono
  • View 1ono
Molmil generated image of 1ono
ISPC MN2+ COMPLEX
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION
Authors:Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F.
Deposit date:2003-02-28
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1ONP
  • Download 1onp
  • View 1onp
Molmil generated image of 1onp
ISPC COMPLEX WITH MN2+ AND FOSMIDOMYCIN
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID
Authors:Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F.
Deposit date:2003-02-28
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J.BIOL.CHEM., 278, 2003
1Q0H
  • Download 1q0h
  • View 1q0h
Molmil generated image of 1q0h
CRYSTAL STRUCTURE OF SELENOMETHIONINE-LABELLED DXR IN COMPLEX WITH FOSMIDOMYCIN
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Mac Sweeney, A., Lange, R., D'Arcy, A., Douangamath, A., Surivet, J.-P., Oefner, C.
Deposit date:2003-07-16
Release date:2004-07-20
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
J.Mol.Biol., 345, 2005
1Q0L
  • Download 1q0l
  • View 1q0l
Molmil generated image of 1q0l
CRYSTAL STRUCTURE OF DXR IN COMPLEX WITH FOSMIDOMYCIN
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mac Sweeney, A., Lange, R., D'Arcy, A., Douangamath, A., Surivet, J.-P., Oefner, C.
Deposit date:2003-07-16
Release date:2004-07-20
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
J.Mol.Biol., 345, 2005
1Q0Q
  • Download 1q0q
  • View 1q0q
Molmil generated image of 1q0q
CRYSTAL STRUCTURE OF DXR IN COMPLEX WITH THE SUBSTRATE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mac Sweeney, A., Lange, R., D'Arcy, A., Douangamath, A., Surivet, J.-P., Oefner, C.
Deposit date:2003-07-17
Release date:2004-07-20
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
J.Mol.Biol., 345, 2005
1R0K
  • Download 1r0k
  • View 1r0k
Molmil generated image of 1r0k
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE FROM ZYMOMONAS MOBILIS
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, ACETATE ION
Authors:Ricagno, S., Grolle, S., Bringer-Meyer, S., Sahm, H., Lindqvist, Y., Schneider, G.
Deposit date:2003-09-22
Release date:2004-07-13
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution.
Biochim.Biophys.Acta, 1698, 2004
1R0L
  • Download 1r0l
  • View 1r0l
Molmil generated image of 1r0l
1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE FROM ZYMOMONAS MOBILIS IN COMPLEX WITH NADPH
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Ricagno, S., Grolle, S., Bringer-Meyer, S., Sahm, H., Lindqvist, Y., Schneider, G.
Deposit date:2003-09-22
Release date:2004-07-13
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution.
Biochim.Biophys.Acta, 1698, 2004
1T1R
  • Download 1t1r
  • View 1t1r
Molmil generated image of 1t1r
CRYSTAL STRUCTURE OF THE REDUCTOISOMERASE COMPLEXED WITH A BISPHOSPHONATE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, SULFATE ION, [(ISOQUINOLIN-1-YLAMINO)-PHOSPHONO-METHYL]-PHOSPHONIC ACID
Authors:Yajima, S., Hara, K., Sanders, J.M., Yin, F., Ohsawa, K., Wiesner, J., Jomaa, H., Oldfield, E.
Deposit date:2004-04-17
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes
J.Am.Chem.Soc., 126, 2004
1T1S
  • Download 1t1s
  • View 1t1s
Molmil generated image of 1t1s
CRYSTAL STRUCTURE OF THE REDUCTOISOMERASE COMPLEXED WITH A BISPHOSPHONATE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, SULFATE ION, MAGNESIUM ION, ...
Authors:Yajima, S., Hara, K., Sanders, J.M., Yin, F., Ohsawa, K., Wiesner, J., Jomaa, H., Oldfield, E.
Deposit date:2004-04-17
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes
J.Am.Chem.Soc., 126, 2004
2C82
  • Download 2c82
  • View 2c82
Molmil generated image of 2c82
X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, SULFATE ION
Authors:Henriksson, L.M., Bjorkelid, C., Mowbray, S.L., Unge, T.
Deposit date:2005-11-30
Release date:2006-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 1.9 A Resolution Structure of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, a Potential Drug Target.
Acta Crystallogr.,Sect.D, 62, 2006
2EGH
  • Download 2egh
  • View 2egh
Molmil generated image of 2egh
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE COMPLEXED WITH A MAGNESIUM ION, NADPH AND FOSMIDOMYCIN
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, MAGNESIUM ION, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ...
Authors:Yajima, S., Hara, K., Iino, D., Sasaki, Y., Kuzuyama, T., Seto, H.
Deposit date:2007-03-01
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin
Acta Crystallogr.,Sect.F, 63, 2007
2JCV
  • Download 2jcv
  • View 2jcv
Molmil generated image of 2jcv
X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH FOSMIDOMYCIN AND NADPH
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
2JCX
  • Download 2jcx
  • View 2jcx
Molmil generated image of 2jcx
X-RAY STRUCTURE OF MUTANT 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH FOSMIDOMYCIN AND NADPH
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
2JCY
  • Download 2jcy
  • View 2jcy
Molmil generated image of 2jcy
X-RAY STRUCTURE OF MUTANT 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, SULFATE ION
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
2JD0
  • Download 2jd0
  • View 2jd0
Molmil generated image of 2jd0
X-RAY STRUCTURE OF MUTANT 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH NADPH
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
2JD1
  • Download 2jd1
  • View 2jd1
Molmil generated image of 2jd1
X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE AND NADPH
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MANGANESE (II) ION, ...
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
2JD2
  • Download 2jd2
  • View 2jd2
Molmil generated image of 2jd2
X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, SULFATE ION
Authors:Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Deposit date:2007-01-04
Release date:2007-05-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.
J.Biol.Chem., 282, 2007
3A06
  • Download 3a06
  • View 3a06
Molmil generated image of 3a06
CRYSTAL STRUCTURE OF DXR FROM THERMOOGA MARITIA, IN COMPLEX WITH FOSMIDOMYCIN AND NADPH
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ...
Authors:Takenoya, M., Ohtaki, A., Noguchi, K., Sasaki, Y., Ohsawa, K., Yohda, M., Yajima, S.
Deposit date:2009-03-02
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
J.Struct.Biol., 170, 2010
3A14
  • Download 3a14
  • View 3a14
Molmil generated image of 3a14
CRYSTAL STRUCTURE OF DXR FROM THERMOTOGA MARITIMA, IN COMPLEX WITH NADPH
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ...
Authors:Takenoya, M., Ohtaki, A., Noguchi, K., Sasaki, Y., Ohsawa, K., Yohda, M., Yajima, S.
Deposit date:2009-03-25
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
J.Struct.Biol., 2010
3ANL
  • Download 3anl
  • View 3anl
Molmil generated image of 3anl
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH PYRIDIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (pyridin-2-ylmethyl)phosphonic acid
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
3ANM
  • Download 3anm
  • View 3anm
Molmil generated image of 3anm
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH 5-PHENYLPYRIDIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, [(5-phenylpyridin-2-yl)methyl]phosphonic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
3ANN
  • Download 3ann
  • View 3ann
Molmil generated image of 3ann
CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH QUINOLIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (quinolin-2-ylmethyl)phosphonic acid
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
<123>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan