1JVS

Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs

Summary for 1JVS

Descriptor1-deoxy-D-xylulose 5-phosphate reductoisomerase, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsreductoisomerase, nadph, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight90402.95
Authors
Yajima, S.,Nonaka, T.,Kuzuyama, T.,Seto, H.,Ohsawa, K. (deposition date: 2001-08-31, release date: 2002-10-09, Last modification date: 2017-10-04)
Primary citation
Yajima, S.,Nonaka, T.,Kuzuyama, T.,Seto, H.,Ohsawa, K.
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding.
J.Biochem.(Tokyo), 131:313-317, 2002
PubMed: 11872159 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers200.5%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution