1JVS
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | polymer | 400 | 44360.0 | 2 | UniProt (P45568) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) | Escherichia coli | |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 397 (UniProt: P45568)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | cloning artifact |
| Mse 41 | Met 42 | modified residue |
| Mse 55 | Met 56 | modified residue |
| Mse 67 | Met 68 | modified residue |
| Mse 87 | Met 88 | modified residue |
| Mse 97 | Met 98 | modified residue |
| Mse 135 | Met 136 | modified residue |
| Mse 200 | Met 201 | modified residue |
| Mse 213 | Met 214 | modified residue |
| Mse 224 | Met 225 | modified residue |
| Mse 225 | Met 226 | modified residue |
| Mse 245 | Met 246 | modified residue |
| Mse 258 | Met 259 | modified residue |
| Mse 275 | Met 276 | modified residue |
| Mse 283 | Met 284 | modified residue |
| Mse 321 | Met 322 | modified residue |
| Mse 366 | Met 367 | modified residue |
| Mse 368 | Met 369 | modified residue |
| Mse 393 | Met 394 | modified residue |
| Ser 398 | - | cloning artifact |
| Ala 399 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88720.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1683.0 | |
| All* | Total formula weight | 90403.0 |
