7S04

1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Acinetobacter baumannii in complex with FR900098, NADPH, and a magnesium ion

Summary for 7S04

• Entry DOI: 10.2210/pdb7s04/pdb
• Descriptor: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[ethanoyl(hydroxy)amino]propylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: isoprenoid biosynthesis, inhibitor, complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 45062.50

Authors

Noble, S.M.,Ball, H.S.,Couch, R.D. (deposition date: 2021-08-28, release date: 2021-11-03, Last modification date: 2023-10-18)

• Primary citation: Ball, H.S.,Girma, M.B.,Zainab, M.,Soojhawon, I.,Couch, R.D.,Noble, S.M.; Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in Acinetobacter baumannii and Klebsiella pneumoniae .; Acs Infect Dis., 7:2987-2998, 2021; PubMed: 34672535; DOI: 10.1021/acsinfecdis.1c00132

Experimental method

X-RAY DIFFRACTION (2.52 Å)