4OOF

M. tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase W203F mutant bound to fosmidomycin and NADPH

Summary for 4OOF

Entry DOI	10.2210/pdb4oof/pdb
Related	3ZHX 4AIC 4OOE
Descriptor	1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	reductoisomerase, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	86508.29
Authors	Allen, C.L.,Kholodar, S.A.,Murkin, A.S.,Gulick, A.M. (deposition date: 2014-01-31, release date: 2014-06-18, Last modification date: 2023-09-20)
Primary citation	Kholodar, S.A.,Tombline, G.,Liu, J.,Tan, Z.,Allen, C.L.,Gulick, A.M.,Murkin, A.S. Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin. Biochemistry, 53:3423-3431, 2014 Cited by PubMed: 24825256 DOI: 10.1021/bi5004074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation