8S65

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors

Summary for 8S65

• Entry DOI: 10.2210/pdb8s65/pdb
• Descriptor: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ... (6 entities in total)
• Functional Keywords: 1-deoxy-d-xylulose-5-phosphate reductoisomerase, structural protein
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 2
• Total formula weight: 105796.46

Authors

Mazzone, F.,Hoeppner, A.,Reiners, J.,Applegate, V.,Abdullaziz, M.,Gottstein, J.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K. (deposition date: 2024-02-26, release date: 2024-08-21)

• Primary citation: Mazzone, F.,Hoeppner, A.,Reiners, J.,Gertzen, C.G.W.,Applegate, V.,Abdullaziz, M.A.,Gottstein, J.,Degrandi, D.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K.; 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterisation and biological evaluation of inhibitors.; Biochem.J., 2024; PubMed: 39105673; DOI: 10.1042/BCJ20240110

Experimental method

SOLUTION SCATTERING
X-RAY DIFFRACTION (2.56 Å)