8S65
1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors
Summary for 8S65
Entry DOI | 10.2210/pdb8s65/pdb |
Descriptor | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ... (6 entities in total) |
Functional Keywords | 1-deoxy-d-xylulose-5-phosphate reductoisomerase, structural protein |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 2 |
Total formula weight | 105796.46 |
Authors | Mazzone, F.,Hoeppner, A.,Reiners, J.,Applegate, V.,Abdullaziz, M.,Gottstein, J.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K. (deposition date: 2024-02-26, release date: 2024-08-21) |
Primary citation | Mazzone, F.,Hoeppner, A.,Reiners, J.,Gertzen, C.G.W.,Applegate, V.,Abdullaziz, M.A.,Gottstein, J.,Degrandi, D.,Wesemann, M.,Kurz, T.,Smits, S.H.,Pfeffer, K. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterisation and biological evaluation of inhibitors. Biochem.J., 2024 Cited by PubMed: 39105673DOI: 10.1042/BCJ20240110 PDB entries with the same primary citation |
Experimental method | SOLUTION SCATTERING X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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