5JO0
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese
Summary for 5JO0
Entry DOI | 10.2210/pdb5jo0/pdb |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid, MANGANESE (II) ION, ... (7 entities in total) |
Functional Keywords | enzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase |
Biological source | Plasmodium falciparum 3D7 |
Cellular location | Plastid, apicoplast : Q8IKG4 |
Total number of polymer chains | 2 |
Total formula weight | 98049.53 |
Authors | Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2016-05-01, release date: 2016-08-24, Last modification date: 2024-01-10) |
Primary citation | Sooriyaarachchi, S.,Chofor, R.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Dowd, C.S.,Maes, L.,Wouters, J.,Jones, T.A.,Van Calenbergh, S.,Mowbray, S.L. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem, 11:2024-2036, 2016 Cited by PubMed: 27487410DOI: 10.1002/cmdc.201600249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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