5JO0
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue L56 A 501 |
| Chain | Residue |
| A | LYS205 |
| A | LYS312 |
| A | GLU315 |
| A | ASP359 |
| A | MN502 |
| A | HOH606 |
| A | HOH632 |
| A | HOH633 |
| A | ASP231 |
| A | SER232 |
| A | GLU233 |
| A | SER269 |
| A | SER270 |
| A | GLY271 |
| A | SER306 |
| A | ASN311 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 502 |
| Chain | Residue |
| A | LYS205 |
| A | ASP231 |
| A | GLU233 |
| A | GLU315 |
| A | L56501 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | SER232 |
| A | GLU233 |
| A | CYS268 |
| A | SER269 |
| A | SER270 |
| A | HIS335 |
| A | CYS338 |
| A | ILE340 |
| A | HIS341 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | SER210 |
| A | ALA211 |
| A | GLY212 |
| A | PHE213 |
| A | ASN413 |
| A | PHE414 |
| A | PRO416 |
| A | THR417 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | TYR357 |
| A | LYS379 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | ARG126 |
| A | ASP326 |
| A | TYR327 |
| A | ASN328 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | TYR113 |
| A | ASN115 |
| A | HIS136 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | SER257 |
| A | ILE262 |
| A | VAL325 |
| A | ASP326 |
| A | ASP329 |
| A | HOH630 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue 6LR A 509 |
| Chain | Residue |
| A | GLN407 |
| A | LYS411 |
| A | LEU448 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue L56 B 501 |
| Chain | Residue |
| B | LYS205 |
| B | ASP231 |
| B | SER232 |
| B | GLU233 |
| B | SER269 |
| B | SER270 |
| B | SER306 |
| B | ASN311 |
| B | LYS312 |
| B | GLU315 |
| B | PRO358 |
| B | ASP359 |
| B | MN502 |
| B | HOH602 |
| B | HOH611 |
| B | HOH662 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 502 |
| Chain | Residue |
| B | LYS205 |
| B | ASP231 |
| B | GLU233 |
| B | GLU315 |
| B | L56501 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | LYS223 |
| B | LEU247 |
| B | THR249 |
| B | GLN253 |
| B | ASN284 |
| B | ASN289 |
| B | HOH634 |
| B | HOH641 |
| B | HOH654 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | GLN407 |
| B | LYS411 |
| B | TYR415 |
| B | SER445 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | SER232 |
| B | GLU233 |
| B | CYS268 |
| B | SER269 |
| B | SER270 |
| B | HIS335 |
| B | CYS338 |
| B | ILE340 |
| B | HIS341 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | VAL209 |
| B | SER210 |
| B | ALA211 |
| B | GLY212 |
| B | PHE213 |
| B | ASN413 |
| B | PHE414 |
| B | PRO416 |
| B | THR417 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | SER183 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | ASP326 |
| B | TYR327 |
| B | ASN328 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O96693","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P45568","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25781377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27487410","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Y67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Y6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JAZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JBI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JO0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
