8JNV

PfDXR - Mn2+ - MAMK89 ternary complex

Summary for 8JNV

• Entry DOI: 10.2210/pdb8jnv/pdb
• Related: 8JNW
• Descriptor: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, MANGANESE (II) ION, [(1~{S})-4-oxidanylidene-4-[oxidanyl(3-phenylpropyl)amino]-1-phenyl-butyl]phosphonic acid, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, isomerase
• Biological source: Plasmodium falciparum HB3
• Total number of polymer chains: 2
• Total formula weight: 94644.85

Authors

Takada, S.,Sakamoto, Y.,Tanaka, N. (deposition date: 2023-06-06, release date: 2024-05-22)

• Primary citation: Abdullaziz, M.A.,Takada, S.,Illarionov, B.,Pessanha de Carvalho, L.,Sakamoto, Y.,Hofmann, S.,Knak, T.,Kiffe-Delf, A.L.,Mazzone, F.,Pfeffer, K.,Kalscheuer, R.,Bacher, A.,Held, J.,Fischer, M.,Tanaka, N.,Kurz, T.; Reverse N -Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).; Acs Infect Dis., 10:1739-1752, 2024; PubMed: 38647213; DOI: 10.1021/acsinfecdis.4c00100

Experimental method

X-RAY DIFFRACTION (1.6 Å)