1E2D
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
Descriptor:ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2E
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE,A MAGNESIUM-ION AND ALF3
Descriptor:ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
Authors:Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2F
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
Descriptor:ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2G
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH ADP, TDP AND A MAGNESIUM-ION
Descriptor:ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2Q
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH TP5A AND A MAGNESIUM-ION
Descriptor:ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Deposit date:2000-05-23
Release date:2001-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E98
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WILD TYPE HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
Descriptor:3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E99
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
Descriptor:3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reinstein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9A
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR AZTP5A
Descriptor:MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9B
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HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND APPNP
Descriptor:3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9C
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MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND APPNP
Descriptor:ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9D
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MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH AZTMP AND ADP
Descriptor:3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9E
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MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH DTMP AND ADP
Descriptor:ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
Deposit date:2000-10-11
Release date:2001-10-11
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1G3U
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
Descriptor:MAGNESIUM ION, SULFATE ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Li de la Sierra, I., Munier-Lehmann, H., Gilles, A.M., Barzu, O., Delarue, M.
Deposit date:2000-10-25
Release date:2001-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.
J.Mol.Biol., 311, 2001
1GSI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
Descriptor:ACETATE ION, MAGNESIUM ION, SULFATE ION, ...
Authors:Ursby, T., Weik, M., Fioravanti, E., Delarue, M., Goeldner, M., Bourgeois, D.
Deposit date:2002-01-03
Release date:2002-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals
Acta Crystallogr.,Sect.D, 58, 2002
1GTV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE-5'-DIPHOSPHATE (TDP)
Descriptor:ACETATE ION, MAGNESIUM ION, SULFATE ION, ...
Authors:Ursby, T., Weik, M., Fioravanti, E., Delarue, M., Goeldner, M., Bourgeois, D.
Deposit date:2002-01-21
Release date:2002-03-28
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals
Acta Crystallogr.,Sect.D, 58, 2002
1MRN
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)
Descriptor:MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ...
Authors:Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
1MRS
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE
Descriptor:5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, MAGNESIUM ION, SULFATE ION, ...
Authors:Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
1N5I
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CRYSTAL STRUCTURE OF INACTIVE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP) AT PH 4.6 (RESOLUTION 1.85 A)
Descriptor:ADENOSINE-5'-TRIPHOSPHATE, CITRATE ANION, SULFATE ION, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-08
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5J
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION)
Descriptor:MAGNESIUM ION, SULFATE ION, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5K
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE (RESOLUTION 2.1 A)
Descriptor:ACETATE ION, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1N5L
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE, AFTER CATALYSIS IN THE CRYSTAL (2.3 A RESOLUTION)
Descriptor:ACETATE ION, DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1NMX
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CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH FLTMP AND ADP
Descriptor:3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMY
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CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH FLTMP AND APPNHP
Descriptor:3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMZ
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CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH NH2TMP AND APPNHP
Descriptor:3'-DEOXY-3'-AMINOTHYMIDINE MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN0
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CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH DDTMP AND ADP
Descriptor:3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
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