4HLC

Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5

Summary for 4HLC

Entry DOI	10.2210/pdb4hlc/pdb
Related	4GFD 4GSY 4HDC 4HEJ 4HLD
Descriptor	Thymidylate kinase, 4-{[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]sulfonyl}-2-(3-methylphenoxy)benzoic acid (3 entities in total)
Functional Keywords	tmk, kinase, thymidylate kinase, mrsa, pipiridine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	2
Total formula weight	47908.24
Authors	Boriack-Sjodin, A.,Olivier, N. (deposition date: 2012-10-16, release date: 2012-10-31, Last modification date: 2024-04-03)
Primary citation	Martinez-Botella, G.,Loch, J.T.,Green, O.M.,Kawatkar, S.P.,Olivier, N.B.,Boriack-Sjodin, P.A.,Keating, T.A. Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK). Bioorg.Med.Chem.Lett., 23:169-173, 2013 Cited by PubMed: 23206863 DOI: 10.1016/j.bmcl.2012.10.128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation