4HLD

Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11

Summary for 4HLD

Entry DOI	10.2210/pdb4hld/pdb
Related	4GFD 4GSY 4HDC 4HEJ 4HLC
Descriptor	Thymidylate kinase, 1-[(3S)-1-{[3-(3-chlorophenoxy)-4-hydroxyphenyl]sulfonyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (3 entities in total)
Functional Keywords	tmk, kinase, thymidylate kinase, mrsa, pipiridine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	2
Total formula weight	47893.06
Authors	Olivier, N. (deposition date: 2012-10-16, release date: 2012-10-31, Last modification date: 2024-02-28)
Primary citation	Martinez-Botella, G.,Loch, J.T.,Green, O.M.,Kawatkar, S.P.,Olivier, N.B.,Boriack-Sjodin, P.A.,Keating, T.A. Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK). Bioorg.Med.Chem.Lett., 23:169-173, 2013 Cited by PubMed: 23206863 DOI: 10.1016/j.bmcl.2012.10.128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation