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8VCH
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BU of 8vch by Molmil
Voltage gated potassium ion channel Kv1.2 W366F, C-type inactivated
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2
Authors:Wu, Y, Sigworth, F.J.
Deposit date:2023-12-14
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Biorxiv, 2024
8VC6
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BU of 8vc6 by Molmil
Voltage gated potassium ion channel Kv1.2 in Potassium
Descriptor: Potassium voltage-gated channel subfamily A member 2
Authors:Wu, Y, Sigworth, F.J.
Deposit date:2023-12-13
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Biorxiv, 2024
8VC3
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BU of 8vc3 by Molmil
Voltage gated potassium ion channel Kv1.2 in complex with DTx
Descriptor: Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2
Authors:Wu, Y, Sigworth, F.J.
Deposit date:2023-12-13
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Biorxiv, 2024
8VC4
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BU of 8vc4 by Molmil
Voltage gated potassium ion channel Kv1.2 in Sodium
Descriptor: Potassium voltage-gated channel subfamily A member 2
Authors:Wu, Y, Sigworth, F.J.
Deposit date:2023-12-13
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Biorxiv, 2024
8QUD
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BU of 8qud by Molmil
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5
Descriptor: (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Lakshminarayana, B, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G.S, Large, C.H, Williams, E, Sauer, D.B.
Deposit date:2023-10-16
Release date:2024-04-03
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Nat Commun, 15, 2024
8QUC
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BU of 8quc by Molmil
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Descriptor: (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G, Large, C, Lakshminaraya, B, Williams, E, Sauer, D.B.
Deposit date:2023-10-16
Release date:2024-04-03
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Nat Commun, 15, 2024
8U7Z
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BU of 8u7z by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(CTD)/Gbeta1gamma2
Descriptor: BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U81
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BU of 8u81 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U82
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BU of 8u82 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U83
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BU of 8u83 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.975 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U80
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BU of 8u80 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD)
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U84
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BU of 8u84 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TEO
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BU of 8teo by Molmil
Shaker in low K+ (4mM K+)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-07-06
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse.
Sci Adv, 9, 2023
8PNM
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BU of 8pnm by Molmil
Structure of human KCTD15 BTB domain mutant G88D crystal form 2
Descriptor: BTB/POZ domain-containing protein KCTD15
Authors:Cruz Walma, D.A, Cros, J, Bradshaw, W, Richardson, W, Chen, Z, Chalk, R, Wilkie, A, Bullock, A.N.
Deposit date:2023-06-30
Release date:2024-03-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
J Med Genet, 61, 2024
8PNR
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BU of 8pnr by Molmil
Structure of human KCTD15 BTB domain mutant G88D crystal form 1
Descriptor: BTB/POZ domain-containing protein KCTD15
Authors:Cruz Walma, D.A, Cros, J, Bradshaw, W, Richardson, W, Chen, Z, Chalk, R, Wilkie, A, Bullock, A.N.
Deposit date:2023-06-30
Release date:2024-03-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
J Med Genet, 61, 2024
8JKB
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BU of 8jkb by Molmil
Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits
Descriptor: BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Authors:Zheng, S, Jiang, W, Wang, W, Kong, Y.
Deposit date:2023-06-01
Release date:2023-07-26
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
8SD3
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BU of 8sd3 by Molmil
CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-06
Release date:2023-09-27
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
8SDA
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BU of 8sda by Molmil
CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-06
Release date:2023-09-27
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
8I79
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BU of 8i79 by Molmil
Cryo-EM structure of KCTD7 in complex with Cullin3
Descriptor: BTB/POZ domain-containing protein KCTD7, Cullin-3
Authors:Jiang, W, Wang, W, Zheng, S.
Deposit date:2023-01-31
Release date:2023-07-26
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
8F1D
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BU of 8f1d by Molmil
Voltage-gated potassium channel Kv3.1 apo
Descriptor: CHOLESTEROL, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1, ...
Authors:Chen, Y, Ishchenko, A.
Deposit date:2022-11-04
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1C
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BU of 8f1c by Molmil
Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one, POTASSIUM ION, ...
Authors:Chen, Y, Ishchenko, A.
Deposit date:2022-11-04
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DFL
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BU of 8dfl by Molmil
Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation)
Descriptor: Nanobody A0194009G09, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3,Green fluorescent protein fusion
Authors:Meyerson, J.R, Selvakumar, P.
Deposit date:2022-06-22
Release date:2022-07-13
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Nat Commun, 13, 2022
7UKC
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BU of 7ukc by Molmil
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKH
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BU of 7ukh by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region
Descriptor: CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ...
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.33 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKE
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BU of 7uke by Molmil
Human Kv4.2-KChIP2 channel complex in an intermediate state, transmembrane region
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022

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