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6JV7
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BU of 6jv7 by Molmil
Chimeric Rat C5a
Descriptor: Chimeric-rC5a, D-anaphylatoxin C5a, SULFATE ION
Authors:Zuo, C.
Deposit date:2019-04-16
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.309 Å)
Cite:Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
4P3A
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BU of 4p3a by Molmil
Crystal structure of the mouse C5a anaphylatoxin
Descriptor: Complement C5, FORMIC ACID
Authors:Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
6JV8
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BU of 6jv8 by Molmil
Crystal structure of Rat C5a
Descriptor: Complement C5
Authors:Zuo, C.
Deposit date:2019-04-16
Release date:2020-04-22
Method:X-RAY DIFFRACTION (1.582 Å)
Cite:Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
4WB2
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BU of 4wb2 by Molmil
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin
Descriptor: ACETATE ION, CALCIUM ION, Complement C5, ...
Authors:Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
Deposit date:2014-09-02
Release date:2015-05-06
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
4WB3
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BU of 4wb3 by Molmil
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin
Descriptor: ACETATE ION, CALCIUM ION, Complement C5, ...
Authors:Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
Deposit date:2014-09-02
Release date:2015-05-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
4P3B
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BU of 4p3b by Molmil
Crystal structure of the mouse C5a-desArg anaphylatoxin
Descriptor: Complement C5, FORMIC ACID
Authors:Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
4UU9
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BU of 4uu9 by Molmil
Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
Descriptor: COMPLEMENT C5, MEDI7814, SULFATE ION
Authors:Colley, C, Sridharan, S, Dobson, C, Popovic, B, Debreczeni, J.E, Hargreaves, D, Edwards, B, Brennan, J, England, L, Fung, S, An Eghobamien, L, Sivars, U, Woods, R, Flavell, L, Renshaw, G.J, Wickson, K, Wilkinson, T, Davies, R, Bonnell, J, Warrener, P, Howes, R, Vaughan, T.
Deposit date:2014-07-25
Release date:2015-08-12
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
MAbs, 10, 2018
4I6O
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BU of 4i6o by Molmil
Crystal structure of chemically synthesized human anaphylatoxin C3a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Complement C3
Authors:Wang, C.I.A, Ghassemian, A, Collins, B, Lewis, R.J, Alewood, P.F, Durek, T.
Deposit date:2012-11-29
Release date:2013-02-27
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Efficient chemical synthesis of human complement protein C3a.
Chem.Commun.(Camb.), 49, 2013
8R5W
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BU of 8r5w by Molmil
Crystal structure of the three anaphylatoxin-like modules in fibulin-2
Descriptor: Fibulin-2
Authors:Sohail, A.A, Koski, M.K, Ruddock, L.W.
Deposit date:2023-11-18
Release date:2024-07-10
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biophysical and structural studies of fibulin-2.
Sci Rep, 14, 2024
4HW5
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BU of 4hw5 by Molmil
Crystal Structure of the Human C3a anaphylatoxin
Descriptor: Complement C3, SULFATE ION
Authors:Bajic, G, Yatime, L, Andersen, G.R.
Deposit date:2012-11-07
Release date:2012-12-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
7AD7
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BU of 7ad7 by Molmil
Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
Deposit date:2020-09-14
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
5B4P
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BU of 5b4p by Molmil
Complex structure of human C5a and its binding repebody
Descriptor: C5a anaphylatoxin, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Kim, H.-S, Choi, J.M, Hwang, D.E.
Deposit date:2016-04-12
Release date:2017-04-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complex structure of human C5a and its binding repebody
To Be Published
4P39
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BU of 4p39 by Molmil
Crystal structure of the human C5aR antagonist C5a-A8
Descriptor: Complement C5
Authors:Yatime, L, Schatz-Jakobsen, J.A, Larsen, C, Andersen, G.R.
Deposit date:2014-03-06
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
7OP0
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BU of 7op0 by Molmil
Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ...
Authors:Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
Deposit date:2021-05-28
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The Chemical Synthesis of Knob Domain Antibody Fragments.
Acs Chem.Biol., 16, 2021
3HQA
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BU of 3hqa by Molmil
Crystal structure of human desarg-C5A
Descriptor: Complement C5
Authors:Cook, W.J, Ealick, S.E.
Deposit date:2009-06-05
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.586 Å)
Cite:Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66, 2010
5HCC
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BU of 5hcc by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3.
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jore, M.M, Johnson, S, Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
4HWJ
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BU of 4hwj by Molmil
Crystal Structure of the Human C3a desArg anaphylatoxin
Descriptor: Complement C3, SULFATE ION
Authors:Bajic, G, Yatime, L, Andersen, G.R.
Deposit date:2012-11-08
Release date:2012-12-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
7AD6
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BU of 7ad6 by Molmil
Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide.
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ...
Authors:Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
Deposit date:2020-09-14
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
8HK2
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BU of 8hk2 by Molmil
C3aR-Gi-C3a protein complex
Descriptor: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ...
Authors:Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E.
Deposit date:2022-11-24
Release date:2023-05-10
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
8OQ3
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BU of 8oq3 by Molmil
Structure of methylamine treated human complement C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gadeberg, T.A.F, Andersen, G.R.
Deposit date:2023-04-11
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of methylamine treated human complement C3
To Be Published
7Y64
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BU of 7y64 by Molmil
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Descriptor: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
Deposit date:2022-06-18
Release date:2023-03-01
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
5HCD
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BU of 5hcd by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ...
Authors:Jore, M.M, Johnson, S, Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
8CEM
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BU of 8cem by Molmil
Structure of bovine native C3, re-refinement
Descriptor: Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Andersen, G.R, Fredslund, F.
Deposit date:2023-02-02
Release date:2023-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
8HK5
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BU of 8hk5 by Molmil
C5aR1-Gi-C5a protein complex
Descriptor: C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E.
Deposit date:2022-11-24
Release date:2023-05-10
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
8B0F
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BU of 8b0f by Molmil
CryoEM structure of C5b8-CD59
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bubeck, D, Couves, E.C, Gardner, S.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023

 

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