Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin

Summary for 4WB2

DescriptorComplement C5, mixed L-RNA/L-DNA mirror-image aptamer NOX-D20 (40-MER), ACETATE ION, ... (6 entities in total)
Functional Keywordsprotein-rna complex, mirror-image aptamer, g-quadruplex, complement anaphylatoxin, dna-rna hybrid
Biological sourceMus musculus (House Mouse)
Cellular locationSecreted P06684
Total number of polymer chains5
Total molecular weight53699.52
Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Vater, A.,Andersen, G.R. (deposition date: 2014-09-02, release date: 2015-05-06, Last modification date: 2018-01-17)
Primary citation
Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Andersen, G.R.,Vater, A.
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6:6481-6481, 2015
PubMed: 25901944 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms7481
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1953 0.5% 0.5% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25