6EGR
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CRYSTAL STRUCTURE OF CITROBACTER FREUNDII METHIONINE GAMMA-LYASE WITH V358Y REPLACEMENT
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Demitri, N., Raboni, S., Nikulin, A.D., Morozova, E.A., Demidkina, T.V., Storici, P., Mozzarelli, A.
Deposit date:2017-09-12
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement
To Be Published
6CJA
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CRYSTAL STRUCTURE OF CYSTATHIONINE BETA-LYASE FROM LEGIONELLA PNEUMOPHILA PHILADELPHIA 1 IN COMPLEX WITH ALANYL-PLP AND SERINE
Descriptor:Cystathionine beta-lyase, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, SERINE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-02-26
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine
to be published
6CJB
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CRYSTAL STRUCTURE OF CYSTATHIONINE BETA-LYASE FROM LEGIONELLA PNEUMOPHILA PHILADELPHIA 1 COVALENTLY BOUND TO PYRIDOXAL PHOSPHATE
Descriptor:Cystathionine beta-lyase, FORMIC ACID, GLYCEROL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-02-26
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 covalently bound to Pyridoxal phosphate
to be published
5TSU
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ACTIVE CONFORMATION FOR ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59N, R119L, E339V) TO DEPLETING METHIONINE
Descriptor:Cystathionine gamma-lyase, METHIONINE, SULFATE ION, ...
Authors:Yan, W., Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5TT2
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INACTIVE CONFORMATION OF ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59N, R119L, E339V) TO DEPLETING METHIONINE
Descriptor:Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W., Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5K30
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII MODIFIED BY S-ETHYL-L-CYSTEINE SULFOXIDE
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, PENTAETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2016-05-19
Release date:2017-07-12
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
To Be Published
5M3Z
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CRYSTAL STRUCTURE OF CITROBACTER FREUNDII METHIONINE GAMMA-LYASE WITH C115H REPLACEMENT IN THE COMPLEX WITH L-NORLEUCINE
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, NORLEUCINE, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2016-10-17
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
5X2V
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE WILD TYPE WITHOUT SULFATE ION
Descriptor:L-methionine gamma-lyase
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2W
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE WILD TYPE WITH L-METHIONINE INTERMEDIATES
Descriptor:L-methionine gamma-lyase, (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2X
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE WILD TYPE WITH L-HOMOCYSTEINE INTERMEDIATES
Descriptor:L-methionine gamma-lyase, (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, HYDROSULFURIC ACID
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2Y
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE C116H MUTANT WITHOUT SULFATE ION
Descriptor:L-methionine gamma-lyase
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2Z
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE C116H MUTANT WITH L-METHIONINE INTERMEDIATES
Descriptor:L-methionine gamma-lyase, (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X30
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CRYSTAL STRUCTURE OF PSEUDOMONAS PUTIDA METHIONINE GAMMA-LYASE C116H MUTANT WITH L-HOMOCYSTEINE INTERMEDIATES.
Descriptor:L-methionine gamma-lyase, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, ...
Authors:Shiba, T., Sato, D., Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5IJG
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CRYSTAL STRUCTURE OF O-ACETYLHOMOSERINE SULFHYDROLASE FROM BRUCELLA MELITENSIS AT 2.0 A RESOLUTION
Descriptor:Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL
Authors:Boyko, K.M., Nikolaeva, A.Y., Koolikova, V.V., Kotlov, M.I., Demidkina, T.V., Popov, V.O.
Deposit date:2016-03-02
Release date:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published
5X5H
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CRYSTAL STRCUTURE OF METB FROM CORYNEBACTERIUM GLUTAMICUM
Descriptor:Cystathionine beta-lyases/cystathionine gamma-synthases, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ...
Authors:Sagong, H.-Y., Kim, K.-J.
Deposit date:2017-02-16
Release date:2017-03-01
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural Insights into Substrate Specificity of Cystathionine gamma-Synthase from Corynebacterium glutamicum
J. Agric. Food Chem., 65, 2017
5EIG
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ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59T, E339V) TO DEPLET CYSTEINE
Descriptor:Cystathionine gamma-lyase, SULFATE ION, CYSTEINE
Authors:Yan, W., Zhang, J.
Deposit date:2015-10-29
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
5E4Z
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH C115A SUBSTITUTION
Descriptor:Methionine gamma-lyase, PENTAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2015-10-07
Release date:2016-10-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii
To Be Published
5D5S
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII, S339A MUTANT
Descriptor:Methionine gamma-lyase, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2015-08-11
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
To Be Published
5DX5
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CLOSTRIDIUM SPOROGENES
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Anufrieva, N.V., Demidkina, T.V.
Deposit date:2015-09-23
Release date:2016-01-13
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure of methionine gamma-lyase from Clostridium sporogenes.
Acta Crystallogr.,Sect.F, 72, 2016
4XQ2
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ENSEMBLE REFINEMENT OF CYSTATHIONE GAMMA LYASE (CALE6) D7G FROM MICROMONOSPORA ECHINOSPORA
Descriptor:CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Wang, F., Yennamalli, R.M., Singh, S., Tan, K., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-18
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
4U1T
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THE CRYSTAL STRUCTURE OF HOLO CALE6, A METHIONINE GAMMA LYASE FROM MICROMONOSPORA ECHINOSPORA
Descriptor:CalE6, SULFATE ION
Authors:Song, H.G., Guo, Z.H.
Deposit date:2014-07-16
Release date:2015-01-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
4U2H
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THE CRYSTAL STRUCTURE OF APO CALE6, A METHIONINE GAMMA LYASE FROM MICROMONOSPORA ECHINOSPORA
Descriptor:CalE6, SULFATE ION
Authors:Song, H.G., Xu, R.
Deposit date:2014-07-17
Release date:2015-01-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
4ITG
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P113S MUTANT OF E. COLI CYSTATHIONINE BETA-LYASE METC
Descriptor:Cystathionine beta-lyase MetC, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Squire, C.J., Yosaatmadja, Y., Soo, V.W.C., Patrick, W.M.
Deposit date:2013-01-18
Release date:2014-12-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:E. coli Cystathionine beta-lyase (MetC) P113S mutant
To be Published
4ITX
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P113S MUTANT OF E. COLI CYSTATHIONINE BETA-LYASE METC INHIBITED BY REACTION WITH L-ALA-P
Descriptor:Cystathionine beta-lyase MetC, {1-[(3-HYDROXY-METHYL-5-PHOSPHONOOXY-METHYL-PYRIDIN-4-YLMETHYL)-AMINO]-ETHYL}-PHOSPHONIC ACID, CALCIUM ION
Authors:Squire, C.J., Yosaatmadja, Y., Soo, V.W.C., Patrick, W.M.
Deposit date:2013-01-19
Release date:2014-12-24
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structure and activity of P113S mutant of E. coli Cystathionine beta-lyase (MetC)
To be Published
4OMA
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THE CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII IN COMPLEX WITH L-CYCLOSERINE PYRIDOXAL-5'-PHOSPHATE
Descriptor:methionine gamma-lyase, [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2014-01-27
Release date:2014-11-26
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine gamma-Lyase from Citrobacter freundii with Inhibitors.
J.Biol.Chem., 290, 2015
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