2GQN

Cystathionine Beta-Lyase (CBL) from Escherichia Coli in complex with N-Hydrazinocarbonylmethyl-2-Nitro-Benzamide

Summary for 2GQN

• Entry DOI: 10.2210/pdb2gqn/pdb
• Related: 2FQ6
• Descriptor: Cystathionine beta-lyase, (5-HYDROXY-6-METHYL-4-((2-(2-(2-NITROBENZAMIDO)ACETYL)HYDRAZINYL)METHYL)PYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE (3 entities in total)
• Functional Keywords: protein-inhibitor complex, plp cofactor covalently bount to blp inhibitor, lyase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm: P06721
• Total number of polymer chains: 2
• Total formula weight: 91803.94

Authors

Summerfield, R.,Junop, M.S. (deposition date: 2006-04-21, release date: 2007-03-06, Last modification date: 2024-02-14)

• Primary citation: Ejim, L.J.,Blanchard, J.E.,Koteva, K.P.,Sumerfield, R.,Elowe, N.H.,Chechetto, J.D.,Brown, E.D.,Junop, M.S.,Wright, G.D.; Inhibitors of Bacterial Cystathionine beta-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function.; J.Med.Chem., 50:755-764, 2007; PubMed: 17300162; DOI: 10.1021/jm061132r

Experimental method

X-RAY DIFFRACTION (1.8 Å)