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5TSN	Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex Descriptor: MANGANESE (II) ION, Norwalk virus polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3') Authors: Shaik, M.M, Ng, K.K. Deposit date: 2016-10-30 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins, 85, 2017
5XE0	Crystal structure of EV-D68-3Dpol in complex with GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein Authors: Xie, W, Wang, C, Wang, Z, Li, Q, Wang, C. Deposit date: 2017-03-30 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol J. Virol., 91, 2017
3KMS	G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure Descriptor: 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... Authors: Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. Deposit date: 2009-11-11 Release date: 2010-07-07 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
5JXS	Mutant GC216/7AA of 3D polymerase from Foot-and-Mouth Disease Virus Descriptor: MAGNESIUM ION, RNA Primer, RNA Template, ... Authors: Verdaguer, N, Ferrer-Orta, C. Deposit date: 2016-05-13 Release date: 2016-06-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication. J.Virol., 90, 2016
7W9S	Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form) Descriptor: CYTIDINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... Authors: Wang, M, Gong, P. Deposit date: 2021-12-10 Release date: 2022-11-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis. Nucleic Acids Res., 50, 2022
8C2P	FMDV 3D polymerase in complex with 3B3 Descriptor: Protein 3B-3, RNA-directed RNA polymerase 3D-POL Authors: Ferrer-Orta, C, Veraguer, N. Deposit date: 2022-12-22 Release date: 2023-04-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes. Plos Pathog., 19, 2023
8C1N	FMDV 3D polymerase in complex with 3B1 protein solved in P212121 space group Descriptor: ACETATE ION, GLYCEROL, Protein 3B-1, ... Authors: Ferrer-Orta, C, Veraguer, N. Deposit date: 2022-12-20 Release date: 2023-04-26 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes. Plos Pathog., 19, 2023
1HHS	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-28 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HHT	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template Descriptor: DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-28 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
3H5Y	Norovirus polymerase+primer/template+CTP complex at 6 mM MnCl2 Descriptor: 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. Deposit date: 2009-04-22 Release date: 2009-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
3H5X	Crystal Structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to Norovirus GII RNA polymerase Descriptor: 2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate), 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', ... Authors: Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. Deposit date: 2009-04-22 Release date: 2009-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
4R0E	Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Low-Fidelity Mutant 3Dpol H273R Descriptor: RNA-directed RNA polymerase Authors: Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M. Deposit date: 2014-07-30 Release date: 2014-11-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase. J.Biol.Chem., 289, 2014
5N8X	Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus Descriptor: 3D polymerase, GLYCEROL, MANGANESE (II) ION Authors: Ferrer-Orta, C, Verdaguer, N. Deposit date: 2017-02-24 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
5N95	Tetragonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus Descriptor: 3D polymerase, TRIPHOSPHATE Authors: Ferrer-Orta, C, Verdaguer, N. Deposit date: 2017-02-24 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
4QPX	NV polymerase post-incorporation-like complex Descriptor: GLYCEROL, MANGANESE (II) ION, Polyprotein, ... Authors: Zamyatkin, D.F, Parra, F, Grochulski, P, Ng, K.K.S. Deposit date: 2014-06-25 Release date: 2015-04-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr.,Sect.D, 70, 2014
6GVV	Mutant M16A of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus Descriptor: GLYCEROL, RNA polymerase 3D Authors: Verdaguer, N, Ferrer Orta, C. Deposit date: 2018-06-21 Release date: 2018-08-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis. J.Virol., 92, 2018
6GVY	Mutant M16A of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus complexed with an template -primer RNA Descriptor: GLYCEROL, Genome polyprotein, RNA (5'-R(P*CP*CP*GP*GP*G)-3'), ... Authors: Verdaguer, N, Ferrer-Orta, C. Deposit date: 2018-06-21 Release date: 2018-08-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis. J. Virol., 92, 2018
5I62	Crystal structure of the insertion loop deletion mutant of the RNA-dependent RNA polymerase of a human picorbirnavirus Descriptor: Potential RNA-dependent RNA polymerase Authors: Collier, A.M, Guo, Y.R, Tao, Y.J. Deposit date: 2016-02-15 Release date: 2016-03-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. Plos Pathog., 12, 2016
5I61	Crystal structure of the RNA-dependent RNA polymerase of a human picorbirnavirus Descriptor: Potential RNA-dependent RNA polymerase Authors: Collier, A.M, Guo, Y.R, Tao, Y.J. Deposit date: 2016-02-15 Release date: 2016-03-16 Last modified: 2019-12-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. Plos Pathog., 12, 2016
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA Descriptor: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BSO	Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA Descriptor: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
4Y34	Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 Descriptor: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... Authors: Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. Deposit date: 2015-02-10 Release date: 2015-04-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
4Y3C	I304V 3D polymerase mutant of EMCV Descriptor: 3D polymerase, CHLORIDE ION, GLYCEROL Authors: Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. Deposit date: 2015-02-10 Release date: 2015-04-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
4Y2C	M300V 3D polymerase mutant of EMCV Descriptor: GLYCEROL, Genome polyprotein Authors: Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. Deposit date: 2015-02-09 Release date: 2015-04-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
3CDU	Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. Deposit date: 2008-02-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008

 

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