1D5F
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STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY
Descriptor:E6AP HECT CATALYTIC DOMAIN, E3 LIGASE
Authors:Huang, L., Kinnucan, E., Wang, G., Beaudenon, S., Howley, P.M., Huibregtse, J.M., Pavletich, N.P.
Deposit date:1999-10-07
Release date:1999-11-17
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science, 286, 1999
1ZVD
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REGULATION OF SMURF2 UBIQUITIN LIGASE ACTIVITY BY ANCHORING THE E2 TO THE HECT DOMAIN
Descriptor:Smad ubiquitination regulatory factor 2, SODIUM ION, PHOSPHATE ION
Authors:Ogunjimi, A.A., Briant, D.J., Pece-Barbara, N., Le Roy, C., Di Guglielmo, G.M., Kavsak, P., Rasmussen, R.K., Seet, B.T., Sicheri, F., Wrana, J.L.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain.
Mol.Cell, 19, 2005
2XBF
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NEDD4 HECT STRUCTURE
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, 1,2-ETHANEDIOL, CALCIUM ION
Authors:Maspero, E., Cecatiello, V., Musacchio, A., Polo, S., Pasqualato, S.
Deposit date:2010-04-09
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
3G1N
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CATALYTIC DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASE HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, SODIUM ION
Authors:Walker, J.R., Qiu, L., Li, Y., Davis, T., Tempel, W., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-01-30
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Hect Domain of Human HUWE1/MULE
To be Published
3H1D
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STRUCTURE OF THE HUWE1 HECT DOMAIN
Descriptor:E3 ubiquitin-protein ligase HUWE1, SULFATE ION
Authors:Partridge, J.R., Schwartz, T.U.
Deposit date:2009-04-11
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
J.Biol.Chem., 285, 2010
3TUG
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CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITIN LIGASE
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, CHLORIDE ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Dobrovetsky, E., Xue, S., Butler, C., Wernimont, A., Walker, J.R., Tempel, W., Dhe-Paganon, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2011-09-16
Release date:2011-10-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
4BE8
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NEDD4 HECT A889F STRUCTURE
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Authors:Maspero, E., Valentini, E., Mari, S., Cecatiello, V., Polo, S., Pasqualato, S.
Deposit date:2013-03-06
Release date:2013-05-01
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.996 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
5LP8
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CRYSTAL STRUCTURE OF AN ASYMMETRIC DIMER OF THE UBIQUITIN LIGASE HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1
Authors:Sander, B., Lorenz, S.G.
Deposit date:2016-08-12
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conformational switch regulates the ubiquitin ligase HUWE1.
Elife, 6, 2017
1C4Z
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STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY
Descriptor:UBIQUITIN-PROTEIN LIGASE E3A, UBIQUITIN CONJUGATING ENZYME E2
Authors:Huang, L., Kinnucan, E., Wang, G., Beaudenon, S., Howley, P.M., Huibregtse, J.M., Pavletich, N.P.
Deposit date:1999-10-14
Release date:1999-11-17
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science, 286, 1999
2XBB
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NEDD4 HECT:UB COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, UBIQUITIN, GLYCEROL
Authors:Maspero, E., Cecatiello, V., Musacchio, A., Polo, S., Pasqualato, S.
Deposit date:2010-04-08
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
4BBN
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NEDD4 HECT-UB:UB COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B
Authors:Maspero, E., Valentini, E., Mari, S., Cecatiello, V., Polo, S., Pasqualato, S.
Deposit date:2012-09-27
Release date:2013-05-01
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
5C7J
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CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPK
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: NEDD4L AND UBV NL.1
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P., Mukherjee, M., Mercredi, P.Y., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPL
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: RSP5 AND UBV R5.4
Descriptor:Rsp5, Ubiquitin variant R5.4
Authors:Wu, K.-P., Kamadurai, H.B., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
3JVZ
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E2~UBIQUITIN-HECT
Descriptor:Ubiquitin-conjugating enzyme E2 D2, E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin
Authors:Souphron, J., Kamadurai, H.B., Schulman, B.A.
Deposit date:2009-09-17
Release date:2010-01-12
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
3JW0
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E2~UBIQUITIN-HECT
Descriptor:Ubiquitin-conjugating enzyme E2 D2, E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin
Authors:Kamadurai, H.B., Schulman, B.A.
Deposit date:2009-09-17
Release date:2010-01-12
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
3OLM
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STRUCTURE AND FUNCTION OF A UBIQUITIN BINDING SITE WITHIN THE CATALYTIC DOMAIN OF A HECT UBIQUITIN LIGASE
Descriptor:E3 ubiquitin-protein ligase RSP5, Ubiquitin
Authors:Kim, H.C., Steffen, A., Chen, J., Huibregtse, J.M.
Deposit date:2010-08-26
Release date:2011-03-23
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structure and function of a HECT domain ubiquitin-binding site.
Embo Rep., 12, 2011
4LCD
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STRUCTURE OF AN RSP5XUBXSNA3 COMPLEX: MECHANISM OF UBIQUITIN LIGATION AND LYSINE PRIORITIZATION BY A HECT E3
Descriptor:E3 ubiquitin-protein ligase RSP5, Protein SNA3, Ubiquitin
Authors:Kamadurai, H.B., Miller, D., Schulman, B.A.
Deposit date:2013-06-21
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.
Elife, 2, 2013
5XMC
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CRYSTAL STRUCTURE OF THE AUTO-INHIBITED NEDD4 FAMILY E3 LIGASE ITCH
Descriptor:E3 ubiquitin-protein ligase Itchy
Authors:Shan, Z., Wen, W.
Deposit date:2017-05-13
Release date:2017-08-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
EMBO Rep., 18, 2017
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