6C9D
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CRYSTAL STRUCTURE OF KA1-AUTOINHIBITED MARK1 KINASE
Descriptor:Serine/threonine-protein kinase MARK1,Serine/threonine-protein kinase MARK1
Authors:Emptage, R.P., Marmorstein, R.
Deposit date:2018-01-26
Release date:2018-07-11
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.
Structure, 26, 2018
5KZ7
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MARK2 COMPLEX WITH 7-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-5,5-DIMETHYL-2-(3-PYRIDYLAMINO)PYRROLO[2,3-D]PYRIMIDIN-6-ONE
Descriptor:Serine/threonine-protein kinase MARK2, 7-[(1~{S})-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one
Authors:Su, H.P., Munshi, S.K.
Deposit date:2016-07-23
Release date:2017-05-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5KZ8
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MARK2 COMPLEX WITH 7-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-5,5-DIMETHYL-2-(3-PYRIDYLAMINO)PYRROLO[2,3-D]PYRIMIDIN-6-ONE
Descriptor:Serine/threonine-protein kinase MARK2, 5,5-dimethyl-7-[(1~{S})-4-oxidanyl-1~{H}-inden-1-yl]-2-phenylazanyl-pyrrolo[2,3-d]pyrimidin-6-one
Authors:Su, H.P., Munshi, S.K.
Deposit date:2016-07-23
Release date:2017-05-31
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5XBO
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LANTHANOID TAGGING VIA AN UNNATURAL AMINO ACID FOR PROTEIN STRUCTURE CHARACTERIZATION
Descriptor:Polyubiquitin-B, UV excision repair protein RAD23 homolog A, TERBIUM(III) ION
Authors:Jiang, W., Gu, X., Dong, X., Tang, C.
Deposit date:2017-03-21
Release date:2017-05-31
Last modified:2017-10-18
Method:SOLUTION NMR
Cite:Lanthanoid tagging via an unnatural amino acid for protein structure characterization
J. Biomol. NMR, 67, 2017
5EAK
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OPTIMIZATION OF MICROTUBULE AFFINITY REGULATING KINASE (MARK) INHIBITORS WITH IMPROVED PHYSICAL PROPERTIES
Descriptor:Serine/threonine-protein kinase MARK2, N-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
Authors:Su, H.P.
Deposit date:2015-10-16
Release date:2016-02-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Bioorg.Med.Chem.Lett., 26, 2016
5DFL
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CRYSTAL STRUCTURE OF UBE2K~UBIQUITIN CONJUGATE
Descriptor:Ubiquitin, Ubiquitin-conjugating enzyme E2 K, GLYCEROL
Authors:Middleton, A.J., Day, C.L.
Deposit date:2015-08-27
Release date:2015-12-02
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.
Sci Rep, 5, 2015
5ES1
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CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR
Descriptor:MAP/microtubule affinity-regulating kinase 4, ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
Authors:Sack, J.S.
Deposit date:2015-11-16
Release date:2015-12-02
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.
Acta Crystallogr F Struct Biol Commun, 72, 2016
4YIR
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CRYSTAL STRUCTURE OF RAD4-RAD23 CROSSLINKED TO AN UNDAMAGED DNA
Descriptor:DNA repair protein RAD4, UV excision repair protein RAD23, DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*GP*CP*TP*AP*CP*AP*A)-3'), ...
Authors:Min, J.-H., Chen, X., Kim, Y.
Deposit date:2015-03-02
Release date:2015-03-11
Method:X-RAY DIFFRACTION (3.0501 Å)
Cite:Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Nat Commun, 6, 2015
2MR9
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NMR STRUCTURE OF UBA DOMAIN OF DNA-DAMAGE-INDUCIBLE 1 PROTEIN (DDI1)
Descriptor:DNA damage-inducible protein 1
Authors:Zhang, D., Fushman, D.
Deposit date:2014-07-02
Release date:2015-02-04
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin.
Structure, 23, 2015
2MRO
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STRUCTURE OF THE COMPLEX OF UBIQUITIN AND THE UBA DOMAIN FROM DNA-DAMAGE-INDUCIBLE 1 PROTEIN (DDI1)
Descriptor:Polyubiquitin-B, DNA damage-inducible protein 1
Authors:Zhang, D., Fushman, D.
Deposit date:2014-07-14
Release date:2015-02-04
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin.
Structure, 23, 2015
2LBC
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SOLUTION STRUCTURE OF TANDEM UBA OF USP13
Descriptor:Ubiquitin carboxyl-terminal hydrolase 13
Authors:Zhang, Y., Zhou, C., Zhou, Z., Song, A., Hu, H.
Deposit date:2011-03-29
Release date:2012-03-07
Method:SOLUTION NMR
Cite:Domain Analysis Reveals That a Deubiquitinating Enzyme USP13 Performs Non-Activating Catalysis for Lys63-Linked Polyubiquitin.
Plos One, 6, 2011
3K9O
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THE CRYSTAL STRUCTURE OF E2-25K AND UBB+1 COMPLEX
Descriptor:Ubiquitin-conjugating enzyme E2 K, Ubiquitin
Authors:Kang, G.B., Ko, S., Song, S.M., Lee, W., Eom, S.H.
Deposit date:2009-10-16
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of E2-25K/UBB+1 Interaction for Neurotoxicity of Alzheimer Disease by Proteasome Inhibition
To be Published
3K9P
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THE CRYSTAL STRUCTURE OF E2-25K AND UBIQUITIN COMPLEX
Descriptor:Ubiquitin-conjugating enzyme E2 K, Ubiquitin
Authors:Kang, G.B., Ko, S., Song, S.M., Lee, W., Eom, S.H.
Deposit date:2009-10-16
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
2KNZ
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NMR STRUCTURE OF CIP75 UBA DOMAIN
Descriptor:Ubiquilin-4
Authors:Kieken, F., Spagnol, G., Su, V., Lau, A.F., Sorgen, P.L.
Deposit date:2009-09-08
Release date:2010-03-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure note: UBA domain of CIP75.
J.Biomol.Nmr, 46, 2010
3IHP
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COVALENT UBIQUITIN-USP5 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin, ZINC ION, ...
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Butler-Cole, C., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-07-30
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Covalent Ubiquitin-Usp5 Complex
To be Published
2WZJ
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CATALYTIC AND UBA DOMAIN OF KINASE MARK2/(PAR-1) K82R, T208E DOUBLE MUTANT
Descriptor:SERINE/THREONINE-PROTEIN KINASE MARK2
Authors:Panneerselvam, S., Marx, A., Mandelkow, E.-M., Mandelkow, E.
Deposit date:2009-11-30
Release date:2009-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.786 Å)
Cite:Structure and Function of Polarity-Inducing Kinase Family Mark/Par-1 within the Branch of Ampk/Snf1-Related Kinases.
Faseb J., 24, 2010
3IEC
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HELICOBACTER PYLORI CAGA INHIBITS PAR1/MARK FAMILY KINASES BY MIMICKING HOST SUBSTRATES
Descriptor:Serine/threonine-protein kinase MARK2, Cytotoxicity-associated immunodominant antigen
Authors:Stebbins, C.E., Nesic, D., Miller, M.
Deposit date:2009-07-22
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
Nat.Struct.Mol.Biol., 17, 2010
3FE3
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CRYSTAL STRUCTURE OF THE KINASE MARK3/PAR-1: T211A-S215A DOUBLE MUTANT
Descriptor:MAP/microtubule affinity-regulating kinase 3
Authors:Nugoor, C., Marx, A., Panneerselvam, S., Mandelkow, E.-M., Mandelkow, E.
Deposit date:2008-11-27
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant
TO BE PUBLISHED
3F92
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CRYSTAL STRUCTURE OF UBIQUITIN-CONJUGATING ENZYME E2-25KDA (HUNTINGTON INTERACTING PROTEIN 2) M172A MUTANT CRYSTALLIZED AT PH 8.5
Descriptor:Ubiquitin-conjugating enzyme E2 K, TETRAETHYLENE GLYCOL, BETA-MERCAPTOETHANOL, ...
Authors:Wilson, R.C., Hughes, R.C., Flatt, J.W., Meehan, E.J., Ng, J.D., Twigg, P.D.
Deposit date:2008-11-13
Release date:2008-11-25
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Acta Crystallogr.,Sect.F, 65, 2009
2R0I
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CRYSTAL STRUCTURE OF A KINASE MARK2/PAR-1 MUTANT
Descriptor:Serine/threonine-protein kinase MARK2
Authors:Panneerselvam, S., Marx, A., Mandelkow, E.-M., Mandelkow, E.
Deposit date:2007-08-20
Release date:2008-08-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Crystal structure of a kinase MARK2/Par-1 mutant
To be Published
3E46
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CRYSTAL STRUCTURE OF UBIQUITIN-CONJUGATING ENZYME E2-25KDA (HUNTINGTON INTERACTING PROTEIN 2) M172A MUTANT
Descriptor:Ubiquitin-conjugating enzyme E2-25 kDa, CALCIUM ION
Authors:Hughes, R.C., Wilson, R.C., Flatt, J.W., Meehan, E.J., Ng, J.D., Twigg, P.D.
Deposit date:2008-08-09
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Acta Crystallogr.,Sect.F, 65, 2009
2JUJ
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SOLUTION STRUCTURE OF THE UBA DOMAIN FROM C-CBL
Descriptor:E3 ubiquitin-protein ligase CBL
Authors:Zhou, Z.R., Hong, J., Lin, D.H., Hu, H.Y.
Deposit date:2007-08-30
Release date:2008-07-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Differential Ubiquitin Binding of the UBA Domains from Human c-Cbl and Cbl-b: NMR Structural and Biochemical Insights.
Protein Sci., 2008
2JY5
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NMR STRUCTURE OF UBIQUILIN 1 UBA DOMAIN
Descriptor:Ubiquilin-1
Authors:Zhang, D., Raasi, S., Fushman, D.
Deposit date:2007-12-06
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains
J.Mol.Biol., 377, 2008
2JY6
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SOLUTION STRUCTURE OF THE COMPLEX OF UBIQUITIN AND UBIQUILIN 1 UBA DOMAIN
Descriptor:Ubiquitin protein, Ubiquilin-1
Authors:Zhang, D., Raasi, S., Fushman, D.
Deposit date:2007-12-06
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains
J.Mol.Biol., 377, 2008
2QSF
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CRYSTAL STRUCTURE OF THE RAD4-RAD23 COMPLEX
Descriptor:DNA repair protein RAD4, UV excision repair protein RAD23
Authors:Min, J.-H., Pavletich, N.P.
Deposit date:2007-07-31
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Nature, 449, 2007
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