5KZ8

Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one

Summary for 5KZ8

• Entry DOI: 10.2210/pdb5kz8/pdb
• Related: 5KZ7
• Descriptor: Serine/threonine-protein kinase MARK2, 5,5-dimethyl-7-[(1~{S})-4-oxidanyl-1~{H}-inden-1-yl]-2-phenylazanyl-pyrrolo[2,3-d]pyrimidin-6-one (2 entities in total)
• Functional Keywords: mark, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Peripheral membrane protein: Q7KZI7
• Total number of polymer chains: 2
• Total formula weight: 80881.04

Authors

Su, H.P.,Munshi, S.K. (deposition date: 2016-07-23, release date: 2017-05-31, Last modification date: 2024-03-06)

• Primary citation: Katz, J.D.,Haidle, A.,Childers, K.K.,Zabierek, A.A.,Jewell, J.P.,Hou, Y.,Altman, M.D.,Szewczak, A.,Chen, D.,Harsch, A.,Hayashi, M.,Warren, L.,Hutton, M.,Nuthall, H.,Su, H.P.,Munshi, S.,Stanton, M.G.,Davies, I.W.,Munoz, B.,Northrup, A.; Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.; Bioorg. Med. Chem. Lett., 27:114-120, 2017; PubMed: 27816515; DOI: 10.1016/j.bmcl.2016.08.068

Experimental method

X-RAY DIFFRACTION (3.21 Å)