5KZ8
Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase MARK2 | polymer | 346 | 40056.1 | 2 | UniProt (Q7KZI7) Pfam (PF00069) Pfam (PF00627) In PDB | Homo sapiens (Human) | ELKL motif kinase 1,EMK-1,MAP/microtubule affinity-regulating kinase 2,PAR1 homolog,PAR1 homolog b,Par1b |
2 | A, B | 5,5-dimethyl-7-[(1~{S})-4-oxidanyl-1~{H}-inden-1-yl]-2-phenylazanyl-pyrrolo[2,3-d]pyrimidin-6-one | non-polymer | 384.4 | 2 | Chemie (6Z5) |
Sequence modifications
A, B: 39 - 364 (UniProt: Q7KZI7)
PDB | External Database | Details |
---|---|---|
Met 19 | - | initiating methionine |
Ala 20 | - | expression tag |
His 21 | - | expression tag |
Asn 22 | - | expression tag |
His 23 | - | expression tag |
Arg 24 | - | expression tag |
His 25 | - | expression tag |
Lys 26 | - | expression tag |
His 27 | - | expression tag |
Ala 28 | - | expression tag |
Asp 29 | - | expression tag |
Tyr 30 | - | expression tag |
Lys 31 | - | expression tag |
Asp 32 | - | expression tag |
Asp 33 | - | expression tag |
Asp 34 | - | expression tag |
Asp 35 | - | expression tag |
Lys 36 | - | expression tag |
Lys 37 | - | expression tag |
Leu 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 80112.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 768.9 | |
All* | Total formula weight | 80881.0 |