5KZ8

Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase MARK2	polymer	346	40056.1	2	UniProt (Q7KZI7) Pfam (PF00069) Pfam (PF00627)	Homo sapiens (Human)	ELKL motif kinase 1,EMK-1,MAP/microtubule affinity-regulating kinase 2,PAR1 homolog,PAR1 homolog b,Par1b
2	C, D (A, B)	5,5-dimethyl-7-[(1~{S})-4-oxidanyl-1~{H}-inden-1-yl]-2-phenylazanyl-pyrrolo[2,3-d]pyrimidin-6-one	non-polymer		384.4	2	Chemie (6Z5)

Sequence modifications

A, B: 39 - 364 (UniProt: Q7KZI7)

PDB	External Database	Details
Met 19	-	initiating methionine
Ala 20	-	expression tag
His 21	-	expression tag
Asn 22	-	expression tag
His 23	-	expression tag
Arg 24	-	expression tag
His 25	-	expression tag
Lys 26	-	expression tag
His 27	-	expression tag
Ala 28	-	expression tag
Asp 29	-	expression tag
Tyr 30	-	expression tag
Lys 31	-	expression tag
Asp 32	-	expression tag
Asp 33	-	expression tag
Asp 34	-	expression tag
Asp 35	-	expression tag
Lys 36	-	expression tag
Lys 37	-	expression tag
Leu 38	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80112.2
Non-Polymers*	Number of molecules	2
	Total formula weight	768.9
All*	Total formula weight	80881.0

*Water molecules are not included.