1BY1
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DBL HOMOLOGY DOMAIN FROM BETA-PIX
Descriptor:PROTEIN (PIX)
Authors:Aghazadeh, B., Zhu, K., Kubiseski, T.J., Liu, G.A., Pawson, T., Zheng, Y., Rosen, M.K.
Deposit date:1998-10-22
Release date:1999-10-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
1F5X
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NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN
Descriptor:RHO-GEF VAV
Authors:Aghazadeh, B., Rosen, M.K., Lowry, W.E., Huang, X.Y.
Deposit date:2000-06-18
Release date:2000-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
2KR9
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KALIRIN DH1 NMR STRUCTURE
Descriptor:Kalirin
Authors:Gorbatyuk, V.Y., Schiller, M.R., Hoch, J.C.
Deposit date:2009-12-10
Release date:2010-12-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution NMR structure of the first Dbl domain of RhoGEF Kalirin.
To be Published
2Z0Q
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CRYSTAL STRUCTURE OF DH-PH DOMAIN OF RHOGEF3(XPLN)
Descriptor:Rho guanine nucleotide exchange factor 3, SULFATE ION
Authors:Murayama, K., Kato-Murayama, M., Terada, T., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2008-05-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of the Rho-specific guanine nucleotide-exchange factor Xpln
Acta Crystallogr.,Sect.F, 68, 2012
3EO2
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CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMAN NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN
Descriptor:Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
4D0O
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AKAP13 (AKAP-LBC) DH DOMAIN
Descriptor:A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4GYV
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CRYSTAL STRUCTURE OF THE DH DOMAIN OF FARP2
Descriptor:FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X., Zhang, X.
Deposit date:2012-09-05
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
4YON
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P-REX1:RAC1 COMPLEX
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Lucato, C.M., Whisstock, J.C., Ellisdon, A.M.
Deposit date:2015-03-11
Release date:2015-07-01
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
5N6R
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SOLUTION STRUCTURE OF THE DBL-HOMOLOGY DOMAIN OF BCR-ABL
Descriptor:Breakpoint cluster region protein
Authors:Reckel, S., Lohr, F., Buchner, L., Guntert, P., Dotsch, V., Hantschel, O.
Deposit date:2017-02-16
Release date:2017-12-27
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
5N7E
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CRYSTAL STRUCTURE OF THE DBL-HOMOLOGY DOMAIN OF BCR-ABL IN COMPLEX WITH MONOBODY MB(BCR-DH_4).
Descriptor:Mb(Bcr-DH_4), Breakpoint cluster region protein
Authors:Reckel, S., Reynaud, A., Pojer, F., Hantschel, O.
Deposit date:2017-02-20
Release date:2017-12-27
Method:X-RAY DIFFRACTION (1.647 Å)
Cite:Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
5O33
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A STRUCTURE OF THE GEF KALIRIN DH1 DOMAIN IN COMPLEX WITH THE SMALL GTPASE RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, Kalirin, 1,2-ETHANEDIOL, ...
Authors:Gray, J., Krojer, T., Talon, R., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
Deposit date:2017-05-23
Release date:2017-05-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
To Be Published
1TXD
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF LEUKEMIA-ASSOCIATED RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 12
Authors:Kristelly, R., Gao, G., Tesmer, J.J.
Deposit date:2004-07-03
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
1X86
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF LEUKEMIA-ASSOCIATED RHOGEF IN COMPLEX WITH RHOA
Descriptor:Rho guanine nucleotide exchange factor 12, Transforming protein RhoA, PHOSPHATE ION
Authors:Kristelly, R., Gao, G., Tesmer, J.J.
Deposit date:2004-08-17
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
1XCG
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CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF PDZRHOGEF
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
Authors:Derewenda, U., Oleksy, A., Stevenson, A.S., Korczynska, J., Dauter, Z., Somlyo, A.P., Otlewski, J., Somlyo, A.V., Derewenda, Z.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
Structure, 12, 2004
2RGN
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CRYSTAL STRUCTURE OF P63RHOGEF COMPLEX WITH GALPHA-Q AND RHOA
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, Rho guanine nucleotide exchange factor 25, Transforming protein RhoA, ...
Authors:Shankaranarayanan, A., Nance, M.R., Tesmer, J.J.G.
Deposit date:2007-10-04
Release date:2008-01-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
3GF9
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEF DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-26
Release date:2009-03-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3KZ1
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CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ-RHOGEF DH/PH DOMAINS WITH GTP-GAMMA-S ACTIVATED RHOA
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, MAGNESIUM ION, ...
Authors:Chen, Z., Sternweis, P.C., Sprang, S.R.
Deposit date:2009-12-07
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
J.Biol.Chem., 285, 2010
3ODO
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODW
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CRYSTAL STRUCTURE OF THE LINKER-DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-11
Release date:2011-01-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3ODX
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CRYSTAL STRUCTURE OF AN N-TERMINALLY TRUNCATED LINKER-DH/PH DOMAINS OF P115-RHOGEF
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-08-12
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3P6A
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CRYSTAL STRUCTURE OF THE DH/PH DOMAINS OF P115-RHOGEF (R399E MUTANT)
Descriptor:Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Guo, L., Sprang, S.R., Sternweis, P.C.
Deposit date:2010-10-11
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Protein Sci., 20, 2011
3T06
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF PDZRHOGEF WITH N-TERMINAL REGULATORY ELEMENTS IN COMPLEX WITH HUMAN RHOA
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
Authors:Bielnicki, J.A., Derewenda, U., Derewenda, Z.S.
Deposit date:2011-07-19
Release date:2011-08-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF.
J.Biol.Chem., 286, 2011
5FI0
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CRYSTAL STRUCTURE OF THE P-REX1 DH/PH TANDEM IN COMPLEX WITH RAC1
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1, PHOSPHATE ION
Authors:Cash, J.N., Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.282 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5FI1
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CRYSTAL STRUCTURE OF THE P-REX1 DH/PH TANDEM IN COMPLEX WITH CDC42
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Cell division control protein 42 homolog
Authors:Cash, J.N., Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5JHG
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE HUMAN RHOA AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL
Authors:Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
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