5UTF
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CRYSTAL STRUCTURE OF A STABILIZED DS-SOSIP.6MUT BG505 GP140 HIV-1 ENV TRIMER, CONTAINING MUTATIONS I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 4.3 A
Descriptor:Envelope glycoprotein gp160, PGT122 Light chain, PGT122 Heavy chain, 35022 Heavy chain, 35022 Light Chain
Authors:Pancera, M., Chuang, G.-Y., Xu, K., Kwong, P.D.
Deposit date:2017-02-14
Release date:2017-03-29
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
J. Virol., 91, 2017
5UTY
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CRYSTAL STRUCTURE OF A STABILIZED DS-SOSIP.MUT4 BG505 GP140 HIV-1 ENV TRIMER, CONTAINING MUTATIONS I201C-P433C (DS), L154M, N300M, N302M, T320L IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 4.1 ANGSTROM
Descriptor:HIV-1 BG505 strain Env gp41, 35O22 Fab heavy chain, 35O22 Fab light chain, HIV-1 BG505 strain Env gp120, PGT122 Fab heavy chain, PGT122 Fab light chain
Authors:Xu, K., Chuang, G.-Y., Pancera, M., Kwong, P.D.
Deposit date:2017-02-15
Release date:2017-03-29
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (3.412 Å)
Cite:Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
J. Virol., 91, 2017
5U6E
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CRYSTAL STRUCTURE OF CLADE A/E HIV-1 GP120 CORE IN COMPLEX WITH NBD-14010
Descriptor:clade A/E 93TH057 HIV-1 gp120 core
Authors:Kwon, Y.D., Debnath, A.K., Kwong, P.D.
Deposit date:2016-12-07
Release date:2017-03-22
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.
J. Med. Chem., 60, 2017
5U1F
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CRYOEM STRUCTURE OF BG505 DS SOSIP TRIMER IN COMPLEX WITH CD4 AND PGT145
Descriptor:BG505 SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, PGT145 light chain, T-cell surface glycoprotein CD4
Authors:Acharya, P., Kwong, P.D., Potter, C.S., Carragher, B.
Deposit date:2016-11-28
Release date:2017-02-22
Last modified:2017-04-19
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Nat. Struct. Mol. Biol., 24, 2017
5TE6
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VRC01-CLASS ANTIBODY N6 IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120 CORE
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, Heavy chain of N6, Light chain of N6
Authors:Zhou, T., Kwong, P.D.
Deposit date:2016-09-20
Release date:2016-11-16
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
5THR
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CRYO-EM STRUCTURE OF A BG505 ENV-SCD4-17B-8ANC195 COMPLEX
Descriptor:T-cell surface glycoprotein CD4, 17b Fab VH domain, BG505 SOSIP gp41 monomer, clade A/E 93TH057 HIV-1 gp120 core, 17b Fb VL domain, 8ANC195 G52K5 VH domain, 8ANC195 G52K5 VL domain
Authors:Wang, H., Bjorkman, P.J.
Deposit date:2016-09-30
Release date:2016-11-16
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T3X
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3.9 ANGSTROM CRYSTAL STRUCTURE OF A FULLY AND NATIVELY GLYCOSYLATED BG505 SOSIP.664 HIV-1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING ANTIBODIES IOMA AND 10-1074.
Descriptor:Endogenous retrovirus group K member 8 Env polyprotein, 10-1074 Heavy Chain, 10-1074 Light Chain, IOMA Heavy Chain, IOMA Light Chain
Authors:Gristick, H.B., Bjorkman, P.J.
Deposit date:2016-08-26
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.
Nat.Struct.Mol.Biol., 23, 2016
5T3Z
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3.5 ANGSTROM CRYSTAL STRUCTURE OF A FULLY AND NATIVELY GLYCOSYLATED BG505 SOSIP.664 HIV-1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING ANTIBODIES IOMA AND 10-1074
Descriptor:Endogenous retrovirus group K member 8 Env polyprotein, 10-1074 Heavy Chain, 10-1074 Light Chain, IOMA Heavy Chain, IOMA Light Chain
Authors:Gristick, H.B., Bjorkman, P.J.
Deposit date:2016-08-26
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.
Nat.Struct.Mol.Biol., 23, 2016
5T3S
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HIV GP140 TRIMER MD39-10MUTA IN COMPLEX WITH FABS PGT124 AND 35022
Descriptor:Endogenous retrovirus group K member 8 Env polyprotein, Fab PGT124 light chain, Fab PGT124 heavy chain, Fab 35022 heavy chain, Fab 35022 light chain
Authors:Stanfield, R.L., Wilson, I.A.
Deposit date:2016-08-26
Release date:2016-09-28
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.
Immunity, 45, 2016
5D9Q
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CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV-1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING FAB PGT122 AND SCFV NIH45-46
Descriptor:Envelope glycoprotein gp120, Envelope glycoprotein gp41, PGT122 light chain, PGT122 heavy chain, NIH45-46 single chain Fv
Authors:Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A.
Deposit date:2015-08-18
Release date:2016-08-17
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Plos Pathog., 12, 2016
5KJR
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CRYSTAL STRUCTURE OF THE ADCC-POTENT ANTIBODY N60-I3 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 W69A/S115W MUTANT AND M48U1.
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, M48U1 CD4 MIMETIC PEPTIDE, N60-I3 FAB HEAVY CHAIN, N60-I3 FAB LIGHT CHAIN
Authors:Tolbert, W.D., Pazgier, M.
Deposit date:2016-06-20
Release date:2016-07-20
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
J.Virol., 90, 2016
5JS9
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 8-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, gp41, broadly neutralizing antibody 8ANC195 heavy chain, broadly neutralizing antibody 8ANC195 light chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 10-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, gp41, broadly neutralizing antibody 8ANC195 heavy chain, broadly neutralizing antibody 8ANC195 light chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5I8H
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH V3 LOOP-TARGETING ANTIBODY PGT122 FAB AND FUSION PEPTIDE-TARGETING ANTIBODY VRC34.01 FAB
Descriptor:BG505 SOSIP.664 gp120, BG505 SOSIP.664 gp41, PGT122 Fab light chain, VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, PGT122 Fab heavy chain
Authors:Xu, K., Zhou, T., Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
5FYK
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CRYSTAL STRUCTURE AT 3.7 A RESOLUTION OF FULLY GLYCOSYLATED HIV-1 CLADE B JR-FL SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122, 35O22 AND VRC01
Descriptor:JR-FL, GP41 ENV ECTODOMAIN, 35O22, JR-FL, GP120 ENV ECTODOMAIN, PGT122, VRC01
Authors:Stewart-Jones, G.B.E., Zhou, T., Thomas, P.V., Kwong, P.D.
Deposit date:2016-03-08
Release date:2016-04-27
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (3.107 Å)
Cite:Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Cell(Cambridge,Mass.), 165, 2016
5FYL
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CRYSTAL STRUCTURE AT 3.7 A RESOLUTION OF FULLY GLYCOSYLATED HIV-1 CLADE A BG505 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122 AND 35O22
Descriptor:BG505 GP120 ENV ECTODOMAIN, 35O22 ANTIBODY FAB HEAVY CHAIN, 35O22 ANTIBODY FAB LIGHT CHAIN, PGT122 ANTIBODY FAB HEAVY CHAIN, PGT122 ANTIBODY FAB LIGHT CHAIN
Authors:Stewart-Jones, G.B.E., Zhou, T., Thomas, P.V., Kwong, P.D.
Deposit date:2016-03-08
Release date:2016-04-27
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Cell(Cambridge,Mass.), 165, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Critical determinants in the emergence of broadly neutralizing CD4-binding site antibodies from an HIV-1-infected Chinese donor
Immunity, 2015
5FA2
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CRYSTAL STRUCTURE OF 426C.TM4DELTAV1-3 P120
Descriptor:gp120
Authors:Scharf, L., Bjorkman, P.J.
Deposit date:2015-12-10
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for germline antibody recognition of HIV-1 immunogens.
Elife, 5, 2016
5F9O
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY CH235.09 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, CH235.9 Heavy chain, CH235.09 Light chain
Authors:Joyce, M.G., Mascola, J.R., Kwong, P.D.
Deposit date:2015-12-10
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
5FCU
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CRYSTAL STRUCTURE OF THE INNER DOMAIN OF CLADE A/E HIV-1 GP120 IN COMPLEX WITH THE ADCC-POTENT RHESUS MACAQUE ANTIBODY JR4
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, JR4 FAB HEAVY CHAIN, JR4 FAB LIGHT CHAIN
Authors:Gohain, N., Tolbert, W.D., Pazgier, M.
Deposit date:2015-12-15
Release date:2016-03-16
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Structure, 24, 2016
5F96
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY CH235.12 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, HEAVY CHAIN OF ANTIBODY CH235.12, LIGHT CHAIN OF ANTIBODY CH235.12
Authors:Zhou, T., Kwong, P.D.
Deposit date:2015-12-09
Release date:2016-03-09
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.2407 Å)
Cite:Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
5F9W
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1-46 GERMLINE-DERIVED CD4-BINDING SITE-DIRECTED ANTIBODY CH235 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, Heavy chain of CH235-lineage antibody CH235, Light chain of CH235-lineage antibody CH235
Authors:Chen, L., Zhou, T., Kwong, P.D.
Deposit date:2015-12-10
Release date:2016-03-09
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.8911 Å)
Cite:Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
5FUU
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ECTODOMAIN OF CLEAVED WILD TYPE JR-FL ENVDCT TRIMER IN COMPLEX WITH PGT151 FAB
Descriptor:HIV-1 ENVELOPE GLYCOPROTEIN GP160, IMMUNOGLOBULIN G PGT151
Authors:Lee, J.H., Ward, A.B.
Deposit date:2016-01-29
Release date:2016-03-09
Last modified:2016-03-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-Em Structure of a Native, Fully Glycosylated and Cleaved HIV-1 Envelope Trimer
Science, 351, 2016
5F6J
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CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH427 FROM A RHESUS MACAQUE IN COMPLEX WITH HIV-1 GP120 CORE
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (6.63 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5CEZ
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CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV-1 ENV TRIMER IN COMPLEX WITH AN EARLY PUTATIVE PRECURSOR OF THE PGT121 FAMILY AT 3.0 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 3H+109L Fab Light Chain, 3H+109L Fab Heavy Chain, 35022 Fab Heavy Chain, 35022 Fab Light Chain
Authors:Wilson, I.A., Garces, F.
Deposit date:2015-07-08
Release date:2015-12-23
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.031 Å)
Cite:Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity, 43, 2015
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