8EUV

Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-COMBO1 FAB

Summary for 8EUV

• Entry DOI: 10.2210/pdb8euv/pdb
• EMDB information: 28618
• Descriptor: Envelope glycoprotein gp120, Envelope glycoprotein gp41, VRC34.01-COMBO1 FAB variable heavy chain, ... (9 entities in total)
• Functional Keywords: broadly neutralizing antibody, fusion peptide, hiv-1, glycoprotein, viral protein, fp-targeting vaccines, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 372641.81

Authors

Pletnev, S.,Kwong, P. (deposition date: 2022-10-19, release date: 2023-09-27, Last modification date: 2024-02-14)

• Primary citation: Banach, B.B.,Pletnev, S.,Olia, A.S.,Xu, K.,Zhang, B.,Rawi, R.,Bylund, T.,Doria-Rose, N.A.,Nguyen, T.D.,Fahad, A.S.,Lee, M.,Lin, B.C.,Liu, T.,Louder, M.K.,Madan, B.,McKee, K.,O'Dell, S.,Sastry, M.,Schon, A.,Bui, N.,Shen, C.H.,Wolfe, J.R.,Chuang, G.Y.,Mascola, J.R.,Kwong, P.D.,DeKosky, B.J.; Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.; Nat Commun, 14:7593-7593, 2023; PubMed: 37989731; DOI: 10.1038/s41467-023-42098-5

Experimental method

ELECTRON MICROSCOPY (2.6 Å)