8G6U

Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074

Summary for 8G6U

• Entry DOI: 10.2210/pdb8g6u/pdb
• EMDB information: 29783
• Descriptor: CRF01_AE T/F100 HIV-1 gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: t/f100 sosip, clade a/e hiv-1, 8anc195, 10-1074, lmhs mutant., viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 18
• Total formula weight: 546003.07

Authors

Chen, Y.,Zhou, F.,Huang, R.,Tolbert, W.,Pazgier, M. (deposition date: 2023-02-16, release date: 2023-11-08)

• Primary citation: Prevost, J.,Chen, Y.,Zhou, F.,Tolbert, W.D.,Gasser, R.,Medjahed, H.,Nayrac, M.,Nguyen, D.N.,Gottumukkala, S.,Hessell, A.J.,Rao, V.B.,Pozharski, E.,Huang, R.K.,Matthies, D.,Finzi, A.,Pazgier, M.; Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.; Nat Commun, 14:6710-6710, 2023; PubMed: 37872202; DOI: 10.1038/s41467-023-42500-2

Experimental method

ELECTRON MICROSCOPY (3.16 Å)