8G6U
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E, I | CRF01_AE T/F100 HIV-1 gp120 | polymer | 485 | 54697.1 | 3 | UniProt (A0A6C0ZY47) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | B, F, J | CRF-1_AE T/F100 HIV-1 gp41 | polymer | 155 | 17389.8 | 3 | UniProt (A0A6C0ZY47) Pfam (PF00517) UniProt (by SIFTS) (B0EZY8) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
3 | C, G, K | Heavy chain of 8ANC195 | polymer | 238 | 25324.4 | 3 | Homo sapiens (human) | ||
4 | D, H, L | Light chain of 8ANC195 | polymer | 215 | 23460.0 | 3 | Homo sapiens (human) | ||
5 | M, O, Q | Heavy chain of 10-1074 | polymer | 238 | 25661.7 | 3 | Homo sapiens (human) | ||
6 | N, P, R | Light chain of 10-1074 | polymer | 214 | 23180.8 | 3 | Homo sapiens (human) | ||
7 | j, S, a | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 3 | In PDB GlyTouCan (G60230HH) | |||
8 | b, h, k, r, T... | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 6 | In PDB GlyTouCan (G56014GC) | |||
9 | d, n, U | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 3 | In PDB GlyTouCan (G40702WU) | |||
10 | 1, c, 2, f, e... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 21 | In PDB GlyTouCan (G42666HT) | |||
11 | i, s, Z | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
12 | I, A, J, B, E... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 36 | Chemie (NAG) |
Sequence modifications
A, E, I: 30 - 507 (UniProt: A0A6C0ZY47)
B, F, J: 512 - 664 (UniProt: A0A6C0ZY47)
PDB | External Database | Details |
---|---|---|
Tyr 61 | His 60 | engineered mutation |
His 105 | Gln 104 | engineered mutation |
Ile 108 | Val 107 | engineered mutation |
Ser 375 | His 381 | conflict |
- | Ser 462 | deletion |
Asp 474 | Asn 475 | engineered mutation |
Met 475 | Ile 476 | engineered mutation |
Arg 476 | Lys 477 | engineered mutation |
Cys 501 | Ala 502 | conflict |
Arg 508 | - | expression tag |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Arg 511 | - | expression tag |
Arg 512 | - | expression tag |
Arg 513 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 560 | conflict |
Cys 605 | Thr 606 | conflict |
Ala 665 | - | expression tag |
Ala 666 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 18 |
Total formula weight | 509141.3 | |
Branched | Number of molecules | 36 |
Total formula weight | 28898.3 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 7963.5 | |
All* | Total formula weight | 546003.1 |