1NB8
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STRUCTURE OF THE CATALYTIC DOMAIN OF USP7 (HAUSP)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.
Deposit date:2002-12-02
Release date:2003-01-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
1VJV
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CRYSTAL STRUCTURE OF UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 6 (YFR010W) FROM SACCHAROMYCES CEREVISIAE AT 1.74 A RESOLUTION
Descriptor:Ubiquitin carboxyl-terminal hydrolase 6 (E.C.3.1.2.15)
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-29
Release date:2004-09-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of Ubiquitin carboxyl-terminal hydrolase 6 (yfr010w) from Saccharomyces cerevisiae at 1.74 A resolution
To be published
2AYN
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STRUCTURE OF USP14, A PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYME
Descriptor:Ubiquitin carboxyl-terminal hydrolase 14 (E.C.3.1.2.15)
Authors:Hu, M., Li, P., Jeffrey, P.D., Shi, Y.
Deposit date:2005-09-07
Release date:2005-10-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
2GFO
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8 (E.C.3.1.2.15)
Authors:Walker, J.R., Avvakumov, G.V, Xue, S., Newman, E.M., Finerty Jr., P.J., Butler-Cole, C., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-03-22
Release date:2006-04-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2VHF
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STRUCTURE OF THE CYLD USP DOMAIN
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD (E.C.3.1.2.15)
Authors:Komander, D., Lord, C.J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
4M5W
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CRYSTAL STRUCTURE OF THE USP7/HAUSP CATALYTIC DOMAIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7 (E.C.3.4.19.12)
Authors:Molland, K.L., Mesecar, A.D., Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Modification date:2014-09-24
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4M5X
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CRYSTAL STRUCTURE OF THE USP7/HAUSP CATALYTIC DOMAIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7 (E.C.3.4.19.12)
Authors:Mesecar, A.D., Molland, K.L., Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Modification date:2014-09-24
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
5CHT
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CRYSTAL STRUCTURE OF USP18
Descriptor:Ubl carboxyl-terminal hydrolase 18 (E.C.3.4.19.-)
Authors:Fritz, G., Basters, A.
Deposit date:2015-07-10
Release date:2016-06-29
Modification date:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
5CVM
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USP46~UBIQUITIN BEA COVALENT COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 46 (E.C.3.4.19.12), Polyubiquitin-B
Authors:Harris, S.F., Yin, J.
Deposit date:2015-07-27
Release date:2015-10-07
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
5K16
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CRYSTAL STRUCTURE OF FREE UBIQUITIN-SPECIFIC PROTEASE 12
Descriptor:Ubiquitin carboxyl-terminal hydrolase 12 (E.C.3.4.19.12)
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Modification date:2016-08-10
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
1NBF
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CRYSTAL STRUCTURE OF A UBP-FAMILY DEUBIQUITINATING ENZYME IN ISOLATION AND IN COMPLEX WITH UBIQUITIN ALDEHYDE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.
Deposit date:2002-12-02
Release date:2003-01-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
2AYO
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STRUCTURE OF USP14 BOUND TO UBQUITIN ALDEHYDE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 14 (E.C.3.1.2.15)
Authors:Hu, M., Li, P., Jeffrey, P.D., Shi, Y.
Deposit date:2005-09-07
Release date:2005-10-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
2F1Z
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CRYSTAL STRUCTURE OF HAUSP
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7 (E.C.3.1.2.15)
Authors:Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2HD5
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USP2 IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2 (E.C.3.1.2.15), Polyubiquitin
Authors:Renatus, M., Kroemer, M.
Deposit date:2006-06-20
Release date:2006-08-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2.
Structure, 14, 2006
2IBI
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COVALENT UBIQUITIN-USP2 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2 (E.C.3.1.2.15)
Authors:Walker, J.R., Avvakumov, G.V., Bernstein, G., Xue, S., Finerty Jr., P.J., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-09-11
Release date:2006-10-24
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Covalent Ubiquitin-USP2 Complex
To be Published
2Y5B
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STRUCTURE OF USP21 IN COMPLEX WITH LINEAR DIUBIQUITIN-ALDEHYDE
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (E.C.3.1.2.15, 3.4.19.12)
Authors:Ye, Y., Akutsu, M., Reyes-Turcu, F., Enchev, R.I., Wilkinson, K.D., Komander, D.
Deposit date:2011-01-12
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21.
Embo Rep., 12, 2011
3I3T
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CRYSTAL STRUCTURE OF COVALENT UBIQUITIN-USP21 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 21 (E.C.3.1.2.15)
Authors:Neculai, D., Avvakumov, G.V., Walker, J.R., Xue, S., Butler-Cole, C., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-07-21
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3M99
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STRUCTURE OF THE UBP8-SGF11-SGF73-SUS1 SAGA DUB MODULE
Descriptor:Ubp8, SAGA-associated factor 11, Protein SUS1, SAGA-associated factor 73
Authors:Kohler, A., Zimmerman, E., Schneider, M., Hurt, E., Zheng, N.
Deposit date:2010-03-21
Release date:2010-05-05
Modification date:2010-07-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Cell(Cambridge,Mass.), 141, 2010
3MHH
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STRUCTURE OF THE SAGA UBP8/SGF11/SUS1/SGF73 DUB MODULE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8 (E.C.3.1.2.15), Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73
Authors:Samara, N.L., Datta, A.B., Berndsen, C.E., Zhang, X., Yao, T., Cohen, R.E., Wolberger, C.
Deposit date:2010-04-08
Release date:2010-04-21
Modification date:2010-06-09
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural insights into the assembly and function of the SAGA deubiquitinating module.
Science, 328, 2010
3MHS
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STRUCTURE OF THE SAGA UBP8/SGF11/SUS1/SGF73 DUB MODULE BOUND TO UBIQUITIN ALDEHYDE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8 (E.C.3.1.2.15), Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ubiquitin
Authors:Samara, N.L., Datta, A.B., Berndsen, C.E., Zhang, X., Yao, T., Cohen, R.E., Wolberger, C.
Deposit date:2010-04-08
Release date:2010-04-21
Modification date:2010-06-09
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural insights into the assembly and function of the SAGA deubiquitinating module.
Science, 328, 2010
3MTN
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USP21 IN COMPLEX WITH A UBIQUITIN-BASED, USP21-SPECIFIC INHIBITOR
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (E.C.3.1.2.15), UBIQUITIN VARIANT UBV.21.4
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3N3K
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THE CATALYTIC DOMAIN OF USP8 IN COMPLEX WITH A USP8 SPECIFIC INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8 (E.C.3.1.2.15)
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Allali-Hassani, A., Lam, R., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium
Deposit date:2010-05-20
Release date:2010-06-23
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3NHE
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HIGH RESOLUTION STRUCTURE (1.26A) OF USP2A IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2 (E.C.3.1.2.15)
Authors:Schormann, N., DeLucas, L.J., Powell McCombs, D.
Deposit date:2010-06-14
Release date:2010-06-30
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:High resolution structure of USP2a in complex with ubiquitin
To be Published
3V6C
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CRYSTAL STRUCTURE OF USP2 IN COMPLEX WITH MUTATED UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2 (E.C.3.4.19.12)
Authors:Neculai, M., Ernst, A., Sidhu, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2011-12-19
Release date:2012-12-19
Modification date:2013-08-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of USP2 in complex with mutated ubiquitin
To be Published
3V6E
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CRYSTAL STRUCTURE OF USP2 AND A MUTANT FORM OF UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2 (E.C.3.4.19.12)
Authors:Neculai, M., Ernst, A., Sidhu, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2011-12-19
Release date:2012-12-19
Modification date:2013-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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