6F5H

Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor

Summary for 6F5H

Entry DOI	10.2210/pdb6f5h/pdb
Related	5N9R 5N9T
Descriptor	Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	usp7, reversible, inhibitor, selective, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q93009
Total number of polymer chains	2
Total formula weight	84327.20
Authors	Harrison, T.,Gavory, G.,O'Dowd, C.,Helm, M.,Flasz, J.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H.,Feutron-Burton, S.,Rountree, J.S.S. (deposition date: 2017-12-01, release date: 2018-04-11)
Primary citation	O'Dowd, C.R.,Helm, M.D.,Rountree, J.S.S.,Flasz, J.T.,Arkoudis, E.,Miel, H.,Hewitt, P.R.,Jordan, L.,Barker, O.,Hughes, C.,Rozycka, E.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Feutren-Burton, S.,Dvorkin, S.,Gavory, G.,Harrison, T. Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors. ACS Med Chem Lett, 9:238-243, 2018 Cited by PubMed: 29541367 DOI: 10.1021/acsmedchemlett.7b00512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation