Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
A | 0016579 | biological_process | protein deubiquitination |
B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
B | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 1001 |
Chain | Residue |
A | GLN219 |
A | ARG262 |
A | GLY275 |
A | THR276 |
A | LYS277 |
A | LYS278 |
A | HOH1233 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue GOL A 1002 |
Chain | Residue |
A | SER341 |
A | LYS391 |
A | HOH1140 |
A | SER330 |
A | TYR331 |
site_id | AC3 |
Number of Residues | 15 |
Details | binding site for residue CQ5 A 1003 |
Chain | Residue |
A | TYR224 |
A | ASP295 |
A | VAL296 |
A | GLN297 |
A | LEU406 |
A | MET407 |
A | ARG408 |
A | PHE409 |
A | LYS420 |
A | HIS456 |
A | ASN460 |
A | HIS461 |
A | TYR465 |
A | TYR514 |
A | HOH1159 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue SO4 B 1001 |
Chain | Residue |
B | GLY275 |
B | THR276 |
B | LYS277 |
B | LYS278 |
B | HOH1103 |
B | HOH1132 |
B | HOH1154 |
B | HOH1229 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 1002 |
Chain | Residue |
B | GLY475 |
B | THR489 |
B | LYS490 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue CQ5 B 1003 |
Chain | Residue |
B | TYR224 |
B | ASP295 |
B | VAL296 |
B | GLN297 |
B | LEU406 |
B | MET407 |
B | ARG408 |
B | PHE409 |
B | LYS420 |
B | HIS456 |
B | ASN460 |
B | HIS461 |
B | TYR465 |
B | TYR514 |
B | HOH1199 |
Functional Information from PROSITE/UniProt
site_id | PS00972 |
Number of Residues | 16 |
Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ |
Chain | Residue | Details |
A | GLY215-GLN230 | |
site_id | PS00973 |
Number of Residues | 18 |
Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY |
Chain | Residue | Details |
A | TYR448-TYR465 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS223 | |
B | CYS223 | |
Chain | Residue | Details |
A | HIS464 | |
B | HIS464 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
A | ASN218 | electrostatic stabiliser |
A | CYS223 | nucleofuge, nucleophile, proton acceptor, proton donor |
A | HIS464 | proton acceptor, proton donor |
A | ASP481 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
B | ASN218 | electrostatic stabiliser |
B | CYS223 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | HIS464 | proton acceptor, proton donor |
B | ASP481 | electrostatic stabiliser |