5N9T

Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor

Summary for 5N9T

• Entry DOI: 10.2210/pdb5n9t/pdb
• Related: 5N9R
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: usp7, reversible, inhibitor, selective, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q93009
• Total number of polymer chains: 2
• Total formula weight: 84713.36

Authors

Harrison, T.,Gavory, G.,O'Dowd, C.,Helm, M.,Flasz, J.,Arkoudis, E.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H. (deposition date: 2017-02-27, release date: 2017-12-06, Last modification date: 2024-01-17)

• Primary citation: Gavory, G.,O'Dowd, C.R.,Helm, M.D.,Flasz, J.,Arkoudis, E.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H.,Harrison, T.; Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.; Nat. Chem. Biol., 14:118-125, 2018; PubMed: 29200206; DOI: 10.1038/nchembio.2528

Experimental method

X-RAY DIFFRACTION (1.73 Å)