5N9T
Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 357 | 41505.9 | 2 | UniProt (Q93009) Pfam (PF00443) | Homo sapiens (Human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | C, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | G, J (A, B) | 3-[4-(aminomethyl)phenyl]-2-methyl-6-[[4-oxidanyl-1-[(3~{R})-4,4,4-tris(fluoranyl)-3-phenyl-butanoyl]piperidin-4-yl]methyl]pyrazolo[4,3-d]pyrimidin-7-one | non-polymer | 568.6 | 2 | Chemie (8QQ) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 880 | Chemie (HOH) |
Sequence modifications
A, B: 207 - 560 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83011.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1701.7 | |
| All* | Total formula weight | 84713.4 |
