2VHF
Structure of the CYLD USP domain
Summary for 2VHF
Entry DOI | 10.2210/pdb2vhf/pdb |
Related | 1IXD 1WHL 1WHM |
Descriptor | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION (3 entities in total) |
Functional Keywords | cytokine signalling, linkage specificity, deubiquitinating enzyme, lys63- linked, anti-oncogene, thiol protease, cell signalling, phosphorylation, zn-binding domain, ubiquitin, cell cycle, usp domain, cross-brace, nf-kb, b-box, protease, hydrolase, cytoplasm, alternative splicing, ubl conjugation pathway |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9NQC7 |
Total number of polymer chains | 2 |
Total formula weight | 86952.00 |
Authors | Komander, D.,Lord, C.J.,Scheel, H.,Swift, S.,Hofmann, K.,Ashworth, A.,Barford, D. (deposition date: 2007-11-21, release date: 2008-03-11, Last modification date: 2024-05-08) |
Primary citation | Komander, D.,Lord, C.J.,Scheel, H.,Swift, S.,Hofmann, K.,Ashworth, A.,Barford, D. The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module Mol.Cell.Biol., 29:451-, 2008 Cited by PubMed: 18313383DOI: 10.1016/J.MOLCEL.2007.12.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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