1NB8
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STRUCTURE OF THE CATALYTIC DOMAIN OF USP7 (HAUSP)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.
Deposit date:2002-12-02
Release date:2003-01-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
1VJV
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CRYSTAL STRUCTURE OF UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 6 (YFR010W) FROM SACCHAROMYCES CEREVISIAE AT 1.74 A RESOLUTION
Descriptor:Ubiquitin carboxyl-terminal hydrolase 6
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-29
Release date:2004-09-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of Ubiquitin carboxyl-terminal hydrolase 6 (yfr010w) from Saccharomyces cerevisiae at 1.74 A resolution
To be published
2AYN
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STRUCTURE OF USP14, A PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYME
Descriptor:Ubiquitin carboxyl-terminal hydrolase 14
Authors:Hu, M., Li, P., Jeffrey, P.D., Shi, Y.
Deposit date:2005-09-07
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
2GFO
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Finerty Jr., P.J., Butler-Cole, C., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-03-22
Release date:2006-04-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2VHF
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STRUCTURE OF THE CYLD USP DOMAIN
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
Authors:Komander, D., Lord, C.J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
2Y6E
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STRUCTURE OF THE D1D2 DOMAIN OF USP4, THE CONSERVED CATALYTIC DOMAIN
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4, ZINC ION, SULFATE ION
Authors:Luna-Vargas, M.P.A., Faesen, A.C., van Dijk, W.J., Rape, M., Fish, A., Sixma, T.K.
Deposit date:2011-01-20
Release date:2011-04-06
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Dusp-Ubl Domain of Usp4 Enhances its Catalytic Efficiency by Promoting Ubiquitin Exchange.
Nat.Commun., 5, 2014
4M5W
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CRYSTAL STRUCTURE OF THE USP7/HAUSP CATALYTIC DOMAIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, BROMIDE ION
Authors:Molland, K.L., Mesecar, A.D., Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4M5X
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CRYSTAL STRUCTURE OF THE USP7/HAUSP CATALYTIC DOMAIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, BROMIDE ION
Authors:Mesecar, A.D., Molland, K.L., Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
5CHT
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CRYSTAL STRUCTURE OF USP18
Descriptor:Ubl carboxyl-terminal hydrolase 18, ZINC ION
Authors:Fritz, G., Basters, A.
Deposit date:2015-07-10
Release date:2016-06-29
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
5CVM
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USP46~UBIQUITIN BEA COVALENT COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 46, Polyubiquitin-B, ZINC ION
Authors:Harris, S.F., Yin, J.
Deposit date:2015-07-27
Release date:2015-10-07
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
5K16
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CRYSTAL STRUCTURE OF FREE UBIQUITIN-SPECIFIC PROTEASE 12
Descriptor:Ubiquitin carboxyl-terminal hydrolase 12, ZINC ION, GLYCEROL
Authors:Li, H., D'Andrea, A.D., Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5KYB
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CRYSTAL STRUCTURE OF THE APO-FORM OF USP7 CATALYTIC DOMAIN [V302K] MUTANT
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, GLYCEROL
Authors:Rouge, L., Ozen, A.
Deposit date:2016-07-21
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering USP7 Catalytic Domain to Understand the Atomistic Mechanism of Activation
To Be Published
5N9R
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH A POTENT, SELECTIVE AND REVERSIBLE SMALL-MOLECULE INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ...
Authors:Harrison, T., Gavory, G., O'Dowd, C., Helm, M., Flasz, I., Arkoudis, E., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Barker, O., Miel, H.
Deposit date:2017-02-27
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Nat. Chem. Biol., 14, 2018
5N9T
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH A POTENT, SELECTIVE AND REVERSIBLE SMALL-MOLECULE INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ...
Authors:Harrison, T., Gavory, G., O'Dowd, C., Helm, M., Flasz, J., Arkoudis, E., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Barker, O., Miel, H.
Deposit date:2017-02-27
Release date:2017-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Nat. Chem. Biol., 14, 2018
5NGE
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE NON-COVALENT INHIBITOR, FT671
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
Authors:Turnbull, A.P., Krajewski, W.W., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5NGF
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE COVALENT INHIBITOR, FT827
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL
Authors:Krajewski, W.W., Turnbull, A.P., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5UQV
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USP7 IN COMPLEX WITH GNE6640 (4-(2-AMINO-4-ETHYL-5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL)PHENOL)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol
Authors:Murray, J.M., Rouge, L.
Deposit date:2017-02-08
Release date:2017-10-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature, 550, 2017
5UQX
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USP7 IN COMPLEX WITH GNE6776 (6'-AMINO-4'-ETHYL-5'-(4-HYDROXYPHENYL)-N-METHYL-[3,3'-BIPYRIDINE]-6-CARBOXAMIDE)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl[3,3'-bipyridine]-6-carboxamide
Authors:Murray, J.M., Rouge, L.
Deposit date:2017-02-08
Release date:2017-10-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature, 550, 2017
5VS6
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STRUCTURE OF DUB COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ACETATE ION, ...
Authors:Seo, H.-S., Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5VSB
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STRUCTURE OF DUB COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one
Authors:Seo, H.-S., Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5VSK
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STRUCTURE OF DUB COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, ZINC ION
Authors:Seo, H.-Y., Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5WCH
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CRYSTAL STRUCTURE OF A PEPTIDASE
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a peptidase
to be published
5WHC
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USP7 IN COMPLEX WITH CPD2 (4-(3-(1-METHYLPIPERIDIN-4-YL)-1,2,4-OXADIAZOL-5-YL)PHENOL)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol, GLYCEROL
Authors:Murray, J.M., Rouge, L.
Deposit date:2017-07-16
Release date:2017-12-13
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.
J. Med. Chem., 60, 2017
6F5H
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH A 4-HYDROXYPIPERIDINE BASED INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ...
Authors:Harrison, T., Gavory, G., O'Dowd, C., Helm, M., Flasz, J., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Barker, O., Miel, H., Feutron-Burton, S., Rountree, J.S.S.
Deposit date:2017-12-01
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
ACS Med Chem Lett, 9, 2018
6GH9
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USP15 CATALYTIC DOMAIN IN COMPLEX WITH SMALL MOLECULE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Ward, S.J., Gratton, H.E., Caulton, S.G., Emsley, J., Dreveny, I.
Deposit date:2018-05-06
Release date:2018-09-26
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
J. Biol. Chem., 2018
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