1JV2
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, CALCIUM ION, INTEGRIN, ...
Authors:Xiong, J.P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D., Joachimiak, A., Goodman, S.L., Arnaout, M.A.
Deposit date:2001-08-28
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3.
Science, 294, 2001
1L5G
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, CYCLIC ARG-GLY-ASP PEPTIDE, INTEGRIN ALPHA V, ...
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-03-06
Release date:2002-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1M1X
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, Integrin alpha-V, Integrin beta-3, ...
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-06-20
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1TYE
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STRUCTURAL BASIS FOR ALLOSTERY IN INTEGRINS AND BINDING OF LIGAND-MIMETIC THERAPEUTICS TO THE PLATELET RECEPTOR FOR FIBRINOGEN
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CACODYLATE ION, ...
Authors:Xiao, T., Takagi, J., Coller, B.S., Wang, J.-H., Springer, T.A.
Deposit date:2004-07-07
Release date:2004-10-12
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Nature, 432, 2004
1U8C
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A NOVEL ADAPTATION OF THE INTEGRIN PSI DOMAIN REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, CALCIUM ION, Integrin alpha-V, ...
Authors:Xiong, J.P., Stehle, T., Goodman, S.L., Arnaout, M.A.
Deposit date:2004-08-05
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279, 2004
2VC2
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758
Descriptor:2-(S)-[N-(3-PYRIDYLSULFONYL)AMINO]-3-[[2-CARBONYL-5-[2-(PIPERIDIN-4-YL)ETHYL]-THIENO[2,3-B]THIOPHENEYL]AMINO]-PROPIONIC ACID, ALPHA-D-MANNOSE, CALCIUM ION, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-09-18
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDK
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:ALPHA-D-MANNOSE, CACODYLATE ION, CALCIUM ION, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDL
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:ALPHA-D-MANNOSE, CACODYLATE ION, CALCIUM ION, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDM
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, GLYCEROL, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDN
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, EPTIFIBATIDE, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDO
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDP
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDQ
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDR
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
3FCS
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STRUCTURE OF COMPLETE ECTODOMAIN OF INTEGRIN AIIBB3
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, IMIDAZOLE, ...
Authors:Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3FCU
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STRUCTURE OF HEADPIECE OF INTEGRIN AIIBB3 IN OPEN CONFORMATION
Descriptor:ALPHA-D-MANNOSE, CACODYLATE ION, CALCIUM ION, ...
Authors:Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3IJE
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CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALHAVBETA3 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CALCIUM ION, ...
Authors:Xiong, J-.P., Mahalingham, B., Rui, X., Hyman, B.T., Goodman, S.L., Arnaout, M.A.
Deposit date:2009-08-04
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
J.Cell Biol., 186, 2009
3NID
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THE CLOSED HEADPIECE OF INTEGRIN ALPHAIIB BETA3 AND ITS COMPLEX WITH AN ALPAHIIB BETA3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, GLYCEROL, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIF
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:2-ethyl-7-piperazin-1-yl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ALPHA-D-MANNOSE, CALCIUM ION, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIG
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:ALPHA-D-MANNOSE, CALCIUM ION, GLYCEROL, ...
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3T3M
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CALCIUM ION, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3T3P
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CALCIUM ION, ...
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3V4P
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1
Descriptor:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
3V4V
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1 AND RO0505376
Descriptor:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
3VI3
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CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN HEADPIECE (LIGAND-FREE FORM)
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CALCIUM ION, ...
Authors:Nagae, M., Nogi, T., Takagi, J.
Deposit date:2011-09-21
Release date:2012-02-22
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of alpha5beta1 integrin ectodomain: Atomic details of the fibronectin receptor
J.Cell Biol., 197, 2012
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