10MH
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Descriptor:DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ...
Authors:Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Deposit date:1998-08-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
1DCT
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DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Descriptor:DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), PROTEIN (MODIFICATION METHYLASE HAEIII), ...
Authors:Reinisch, K.M., Chen, L., Verdine, G.L., Lipscomb, W.N.
Deposit date:1995-05-17
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell(Cambridge,Mass.), 82, 1995
1FJX
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STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY
Descriptor:DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), HHAI DNA METHYLTRANSFERASE, SULFATE ION, ...
Authors:Vilkaitis, G., Dong, A., Weinhold, E., Cheng, X., Klimasauskas, S.
Deposit date:2000-08-08
Release date:2000-12-15
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase.
J.Biol.Chem., 275, 2000
1G55
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STRUCTURE OF HUMAN DNMT2, AN ENIGMATIC DNA METHYLTRANSFERASE HOMOLOGUE
Descriptor:DNA CYTOSINE METHYLTRANSFERASE DNMT2, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Yoder, J.A., Zhang, X., Zhou, L., Bestor, T.H., Cheng, X.
Deposit date:2000-10-30
Release date:2001-01-17
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
Nucleic Acids Res., 29, 2001
1HMY
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CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE
Descriptor:HaeIII METHYLTRANSFERASE, S-ADENOSYLMETHIONINE
Authors:Cheng, X.
Deposit date:1993-08-05
Release date:1993-10-31
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
Cell(Cambridge,Mass.), 74, 1993
1M0E
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ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE
Descriptor:5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Zhou, L., Cheng, X., Connolly, B.A., Dickman, M.J., Hurd, P.J., Hornby, D.P.
Deposit date:2002-06-12
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES
J.MOL.BIOL., 321, 2002
1MHT
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COVALENT TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE, DNA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:DNA (5'-D(P*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ...
Authors:Cheng, X.
Deposit date:1994-12-08
Release date:1995-06-03
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:HhaI methyltransferase flips its target base out of the DNA helix.
Cell(Cambridge,Mass.), 76, 1994
1SKM
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HHAI METHYLTRANSFERASE IN COMPLEX WITH DNA CONTAINING AN ABASIC SOUTH CARBOCYCLIC SUGAR AT ITS TARGET SITE
Descriptor:5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Horton, J.R., Ratner, G., Banavali, N., Huang, N., Marquez, V.E., MacKerell, A.D., Cheng, X.
Deposit date:2004-03-05
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase
Nucleic Acids Res., 32, 2004
1SVU
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STRUCTURE OF THE Q237W MUTANT OF HHAI DNA METHYLTRANSFERASE: AN INSIGHT INTO PROTEIN-PROTEIN INTERACTIONS
Descriptor:Modification methylase HhaI, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Zhou, L., Zhang, X., Stickel, S., Roberts, R.J., Cheng, X.
Deposit date:2004-03-30
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions
Biol.Chem., 385, 2004
2C7O
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HHAI DNA METHYLTRANSFERASE COMPLEX WITH 13MER OLIGONUCLEOTIDE CONTAINING 2-AMINOPURINE ADJACENT TO THE TARGET BASE (PCGC:GMGC) AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', ...
Authors:Daujotyte, D., Grazulis, S.
Deposit date:2005-11-25
Release date:2005-12-14
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
2C7P
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HHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2- AMINOPURINE OPPOSITE TO THE TARGET BASE (GCGC:GMPC) AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ...
Authors:Neely, R.K., Daujotyte, D., Grazulis, S., Magennis, S.W., Dryden, D.T.F., Klimasauskas, S., Jones, A.C.
Deposit date:2005-11-25
Release date:2005-12-14
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
2C7Q
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HHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2- AMINOPURINE OUTSIDE THE RECOGNITION SEQUENCE (PAIRED WITH G) AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', ...
Authors:Daujotyte, D., Grazulis, S.
Deposit date:2005-11-27
Release date:2005-12-14
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes
Nucleic Acids Res., 33, 2005
2C7R
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HHAI DNA METHYLTRANSFERASE (T250G MUTANT) COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2-AMINOPURINE AS A TARGET BASE (GPGC:GMGC) AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', ...
Authors:Daujotyte, D., Grazulis, S.
Deposit date:2005-11-27
Release date:2005-12-14
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
2HMY
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BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE
Descriptor:PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE
Authors:O'Gara, M., Zhang, X., Roberts, R.J., Cheng, X.
Deposit date:1999-02-08
Release date:1999-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide.
J.Mol.Biol., 287, 1999
2HR1
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TERNARY STRUCTURE OF WT M.HHAI C5-CYTOSINE DNA METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY
Descriptor:5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ...
Authors:Shieh, F.
Deposit date:2006-07-19
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI.
J.Mol.Biol., 362, 2006
2I9K
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ENGINEERED EXTRAHELICAL BASE DESTABILIZATION ENHANCES SEQUENCE DISCRIMINATION OF DNA METHYLTRANSFERASE M.HHAI
Descriptor:5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Youngblood, B., Shieh, F.K., De Los Rios, S., Perona, J.J., Reich, N.O.
Deposit date:2006-09-05
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI
J.Mol.Biol., 362, 2006
2QRV
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STRUCTURE OF DNMT3A-DNMT3L C-TERMINAL DOMAIN COMPLEX
Descriptor:DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Jia, D., Cheng, X.
Deposit date:2007-07-29
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
Nature, 449, 2007
2UYC
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HHAI DNA METHYLTRANSFERASE R163N MUTANT COMPLEX WITH 13MER GCGC-GMGC OLIGONUCLEOTIDE AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', ...
Authors:Daujotyte, D., Grazulis, S.
Deposit date:2007-04-03
Release date:2008-05-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah
To be Published
2UYH
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HHAI DNA METHYLTRANSFERASE S87Q-Q237S MUTANT COMPLEX WITH 13MER GCGC- GMGC OLIGONUCLEOTIDE AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*TP*GP*GP*AP*TP*G*5CMP*GP*CP*TP*GP *AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', ...
Authors:Daujotyte, D., Grazulis, S.
Deposit date:2007-04-06
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:HhaI DNA Methyltransferase S87Q-Q237S Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah
To be Published
2UZ4
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HHAI DNA METHYLTRANSFERASE R165N MUTANT COMPLEX WITH 13MER GCGC-GMGC OLIGONUCLEOTIDE AND SAH
Descriptor:MODIFICATION METHYLASE HHAI, 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', ...
Authors:Daujotyte, D., Leinartaite, L., Grazulis, S.
Deposit date:2007-04-25
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Methyltransferase R165N Mutant
To be Published
2Z6A
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S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFER: OBSERVABLE PRECATALYTIC INTERMEDIATES DURING DNA CYTOSINE METHYLATION
Descriptor:DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ...
Authors:Shieh, F.K.
Deposit date:2007-07-25
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:S-Adenosyl-l-methionine-Dependent Methyl Transfer: Observable Precatalytic Intermediates during DNA Cytosine Methylation
Biochemistry, 46, 2007
2Z6Q
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TERNARY STRUCTURE OF ARG165ALA M.HHAI C5-CYTOSINE DNA METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY
Descriptor:DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DG)-3'), DNA (5'-D(*DGP*DCP*DTP*DAP*DTP*DC)-3'), ...
Authors:Shieh, F.K.
Deposit date:2007-08-08
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:The role of Arg165 towards base flipping, base stabilization and catalysis in M.HhaI
J.Mol.Biol., 362, 2006
2Z6U
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TERNARY STRUCTURE OF THE GLU119ALA M.HHAI, C5-CYTOSINE DNA METHYLTRANSFERASE, WITH UNMODIFIED DNA AND ADOHCY
Descriptor:DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ...
Authors:Shieh, F.K.
Deposit date:2007-08-09
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI
J.Mol.Biol., 373, 2007
2ZCJ
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TERNARY STRUCTURE OF THE GLU119GLN M.HHAI, C5-CYTOSINE DNA METHYLTRANSFERASE, WITH UNMODIFIED DNA AND ADOHCY
Descriptor:DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ...
Authors:Shieh, F.K., Reich, N.O.
Deposit date:2007-11-09
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI
J.Mol.Biol., 373, 2007
3EEO
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M. HHAI CO-CRYSTALLIZED WITH SYNTHETIC DSDNA CONTAINING A PROPANE DIOL IN PLACE OF THE DEOXYCYTIDINE RESIDUE TARGETED FOR METHYLATION.
Descriptor:5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ...
Authors:Porta, J.C., Christman, J.K., Borgstahl, G.E.O.
Deposit date:2008-09-05
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation.
To be Published
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