7X9D
DNMT3B in complex with harmine
Summary for 7X9D
| Entry DOI | 10.2210/pdb7x9d/pdb |
| Descriptor | DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5)-methyltransferase 3-like, 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE (3 entities in total) |
| Functional Keywords | inhibitor, comple, methyltransferase, transferase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 113110.43 |
| Authors | Cho, C.-C.,Yuan, H.S. (deposition date: 2022-03-15, release date: 2023-03-15, Last modification date: 2023-11-29) |
| Primary citation | Cho, C.C.,Lin, C.J.,Huang, H.H.,Yang, W.Z.,Fei, C.Y.,Lin, H.Y.,Lee, M.S.,Yuan, H.S. Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18:1335-1350, 2023 Cited by PubMed: 37188336DOI: 10.1021/acschembio.3c00065 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.08 Å) |
Structure validation
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