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9G11
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BU of 9g11 by Molmil
sugar/H+ symporter STP6 in inward occluded conformation with glucose bound
Descriptor: CHOLESTEROL HEMISUCCINATE, Sugar transport protein 6, beta-D-glucopyranose
Authors:Andersen, C.G, Bavnhoj, L, Pedersen, B.P.
Deposit date:2024-07-09
Release date:2024-08-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Comparative biochemical analysis of the plant sugar transporters STP6 and STP10
To Be Published
8YF1
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BU of 8yf1 by Molmil
Cryo-EM structure of human SV2A in complex with Brivaracetam
Descriptor: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, Synaptic vesicle glycoprotein 2A
Authors:Qu, Q, Liu, S, Zhou, Z.
Deposit date:2024-02-23
Release date:2024-06-12
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structure of human SV2A in complex with Brivaracetam
To Be Published
8YF0
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BU of 8yf0 by Molmil
Cryo-EM structure of human SV2A
Descriptor: Synaptic vesicle glycoprotein 2A
Authors:Qu, Q, Liu, S, Zhou, Z.
Deposit date:2024-02-23
Release date:2024-06-12
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Cryo-EM structure of human SV2A
To Be Published
8Y66
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BU of 8y66 by Molmil
Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin
Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Solute carrier family 2, facilitated glucose transporter member 9
Authors:Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y.
Deposit date:2024-02-01
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural basis for urate recognition and apigenin inhibition of human GLUT9.
Nat Commun, 15, 2024
8Y65
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BU of 8y65 by Molmil
Cryo-EM structure of human urate transporter GLUT9 bound to substrate urate
Descriptor: Solute carrier family 2, facilitated glucose transporter member 9, URIC ACID
Authors:Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y.
Deposit date:2024-02-01
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structural basis for urate recognition and apigenin inhibition of human GLUT9.
Nat Commun, 15, 2024
8WJH
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BU of 8wjh by Molmil
Cryo-EM structure of OAT4
Descriptor: CHLORIDE ION, Solute carrier family 22 member 11
Authors:Qian, H.W, He, J.J.
Deposit date:2023-09-26
Release date:2024-08-28
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the transport and substrate selection of human urate transporter 1.
Cell Rep, 43, 2024
8UOA
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BU of 8uoa by Molmil
Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, Synaptic vesicle glycoprotein 2A, ...
Authors:Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
Deposit date:2023-10-19
Release date:2024-05-22
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8UO9
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BU of 8uo9 by Molmil
Structure of synaptic vesicle protein 2A in complex with a nanobody
Descriptor: (4R)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
Deposit date:2023-10-19
Release date:2024-05-22
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8UO8
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BU of 8uo8 by Molmil
Structure of synaptic vesicle protein 2B with padsevonil
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[(4R)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], ...
Authors:Martin, M.F, Mittal, A, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
Deposit date:2023-10-19
Release date:2024-05-22
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8SDZ
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BU of 8sdz by Molmil
Structure of rat organic anion transporter 1 (OAT1) in complex with probenecid
Descriptor: 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SDY
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BU of 8sdy by Molmil
Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH)
Descriptor: N-(4-aminobenzoyl)glycine, Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SDU
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BU of 8sdu by Molmil
Structure of rat organic anion transporter 1 (OAT1)
Descriptor: Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.05 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SC6
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BU of 8sc6 by Molmil
Human OCT1 bound to thiamine in inward-open conformation
Descriptor: 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC4
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BU of 8sc4 by Molmil
Human OCT1 bound to metformin in inward-open conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC3
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BU of 8sc3 by Molmil
Human OCT1 bound to fenoterol in inward-open conformation
Descriptor: Fenoterol, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC2
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BU of 8sc2 by Molmil
Human OCT1 bound to diltiazem in inward-open conformation
Descriptor: Diltiazem, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC1
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BU of 8sc1 by Molmil
Human OCT1 (Apo) in inward-open conformation
Descriptor: Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8OMU
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BU of 8omu by Molmil
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state
Descriptor: Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2023-03-31
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8K77
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BU of 8k77 by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam
Descriptor: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yamagata, A.
Deposit date:2023-07-26
Release date:2024-05-01
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JU0
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BU of 8ju0 by Molmil
hOCT1 in complex with spironolactone in inward facing occluded conformation
Descriptor: SPIRONOLACTONE, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-23
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTZ
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BU of 8jtz by Molmil
hOCT1 in complex with spironolactone in outward facing partially occluded conformation
Descriptor: SPIRONOLACTONE, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTY
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BU of 8jty by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 2 conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTX
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BU of 8jtx by Molmil
hOCT1 in complex with nb5660 in inward facing fully open conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTW
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BU of 8jtw by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 1 conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTV
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BU of 8jtv by Molmil
hOCT1 in complex with metformin in inward occluded conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024

 

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