8SDZ
Structure of rat organic anion transporter 1 (OAT1) in complex with probenecid
Summary for 8SDZ
Entry DOI | 10.2210/pdb8sdz/pdb |
EMDB information | 40355 |
Descriptor | Solute carrier family 22 member 6, 4-(dipropylsulfamoyl)benzoic acid (3 entities in total) |
Functional Keywords | organic anion transporter, oat, slc22, drug transporter, probenecid, transport protein |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 1 |
Total formula weight | 61102.19 |
Authors | |
Primary citation | Dou, T.,Lian, T.,Shu, S.,He, Y.,Jiang, J. The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. Nat.Struct.Mol.Biol., 30:1794-1805, 2023 Cited by PubMed: 37845412DOI: 10.1038/s41594-023-01123-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.86 Å) |
Structure validation
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