8JTV

hOCT1 in complex with metformin in inward occluded conformation

Summary for 8JTV

• Entry DOI: 10.2210/pdb8jtv/pdb
• EMDB information: 36653
• Descriptor: Solute carrier family 22 member 1, Metformin (2 entities in total)
• Functional Keywords: slc, transporter, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 62698.33

Authors

Zhang, S.,Zhu, A.,Kong, F.,Chen, J.,Lan, B.,He, G.,Gao, K.,Cheng, L.,Yan, C.,Chen, L.,Liu, X. (deposition date: 2023-06-22, release date: 2024-03-27)

• Primary citation: Zhang, S.,Zhu, A.,Kong, F.,Chen, J.,Lan, B.,He, G.,Gao, K.,Cheng, L.,Sun, X.,Yan, C.,Chen, L.,Liu, X.; Structural insights into human organic cation transporter 1 transport and inhibition.; Cell Discov, 10:30-30, 2024; PubMed: 38485705; DOI: 10.1038/s41421-024-00664-1

Experimental method

ELECTRON MICROSCOPY (3.77 Å)