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1A7C
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HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-ribopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAPEPTIDE, ...
Authors:Xue, Y, Inghardt, T, Sjolin, L, Deinum, J.
Deposit date:1998-03-12
Release date:1999-03-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
Structure, 6, 1998
1ANT
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BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN
Descriptor: ANTITHROMBIN
Authors:Carrell, R.W, Stein, P.E, Fermi, G, Wardell, M.R.
Deposit date:1994-02-28
Release date:1995-01-26
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biological implications of a 3 A structure of dimeric antithrombin.
Structure, 2, 1994
1AS4
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CLEAVED ANTICHYMOTRYPSIN A349R
Descriptor: ACETATE ION, ANTICHYMOTRYPSIN
Authors:Lukacs, C.M, Christianson, D.W.
Deposit date:1997-08-12
Release date:1998-02-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
1ATH
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THE INTACT AND CLEAVED HUMAN ANTITHROMBIN III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS
Descriptor: ANTITHROMBIN III
Authors:Schreuder, H.A, Hol, W.G.J.
Deposit date:1993-12-14
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions.
Nat.Struct.Biol., 1, 1994
1ATT
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CRYSTAL STRUCTURE OF CLEAVED BOVINE ANTITHROMBIN III AT 3.2 ANGSTROMS RESOLUTION
Descriptor: ANTITHROMBIN III
Authors:Mourey, L, Samama, J.P, Delarue, M, Moras, D.
Deposit date:1993-03-29
Release date:1994-07-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution.
J.Mol.Biol., 232, 1993
1ATU
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UNCLEAVED ALPHA-1-ANTITRYPSIN
Descriptor: ALPHA-1-ANTITRYPSIN
Authors:Ryu, S.-E, Choi, H.-J.
Deposit date:1997-05-11
Release date:1997-08-20
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A.
Structure, 4, 1996
1AZX
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ANTITHROMBIN/PENTASACCHARIDE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ANTITHROMBIN
Authors:Jin, L, Abrahams, J.P, Skinner, R, Petitou, M, Pike, R.N, Carrell, R.W.
Deposit date:1997-11-23
Release date:1999-01-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
1B3K
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Plasminogen activator inhibitor-1
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Sharp, A.M, Stein, P.E, Pannu, N.S, Read, R.J.
Deposit date:1998-12-11
Release date:1999-12-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.
Structure Fold.Des., 7, 1999
1BR8
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IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN
Descriptor: PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE)
Authors:Skinner, R, Chang, W.S.W, Jin, L, Pei, X.Y, Huntington, J.A, Abrahams, J.P, Carrell, R.W, Lomas, D.A.
Deposit date:1998-08-26
Release date:1998-09-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
J.Mol.Biol., 283, 1998
1BY7
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HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2. LOOP (66-98) DELETION MUTANT
Descriptor: PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-2)
Authors:Harrop, S.J, King, G.C, Mabbutt, B.C, Curmi, P.M.G.
Deposit date:1998-10-27
Release date:1999-10-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
Structure Fold.Des., 7, 1999
1C5G
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PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Goldsmith, E.J.
Deposit date:1999-12-07
Release date:1999-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition.
Nat.Struct.Biol., 2, 1995
1C8O
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2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA
Descriptor: ICE INHIBITOR
Authors:Simonovic, M, Gettins, P.G.W, Volz, K.
Deposit date:2000-06-01
Release date:2000-09-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition.
Protein Sci., 9, 2000
1D5S
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CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
Descriptor: P1-ARG ANTITRYPSIN
Authors:Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P.
Deposit date:1999-10-11
Release date:2000-04-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
1DB2
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CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P.
Deposit date:1999-11-02
Release date:1999-11-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
1DVM
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ACTIVE FORM OF HUMAN PAI-1
Descriptor: CHLORIDE ION, PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Stout, T.J, Graham, H, Buckley, D.I, Matthews, D.J.
Deposit date:2000-01-21
Release date:2000-09-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
Biochemistry, 39, 2000
1DVN
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LATENT FORM OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Stout, T.J, Graham, H, Buckley, D.I, Matthews, D.J.
Deposit date:2000-01-21
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
Biochemistry, 39, 2000
1DZG
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N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:McCoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1DZH
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P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:Mccoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1E03
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PLASMA ALPHA ANTITHROMBIN-III AND PENTASACCHARIDE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
Authors:McCoy, A.J, Jin, L, Abrahams, J.-P, Skinner, R, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1E04
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PLASMA BETA ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, GLYCEROL, ...
Authors:Mccoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1E05
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PLASMA ALPHA ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:McCoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1EZX
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CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor: ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A, Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
1F0C
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STRUCTURE OF THE VIRAL SERPIN CRMA
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ICE INHIBITOR
Authors:Renatus, M, Zhou, Q, Stennicke, H.R, Snipas, S.J, Turk, D, Bankston, L.A, Liddington, R.C, Salvesen, G.S.
Deposit date:2000-05-15
Release date:2000-09-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold.Des., 8, 2000
1HLE
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CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, HORSE LEUKOCYTE ELASTASE INHIBITOR
Authors:Baumann, U, Bode, W, Huber, R, Travis, J, Potempa, J.
Deposit date:1992-04-13
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution.
J.Mol.Biol., 226, 1992
1HP7
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A 2.1 ANGSTROM STRUCTURE OF AN UNCLEAVED ALPHA-1-ANTITRYPSIN SHOWS VARIABILITY OF THE REACTIVE CENTER AND OTHER LOOPS
Descriptor: ALPHA-1-ANTITRYPSIN, BETA-MERCAPTOETHANOL, ZINC ION
Authors:Kim, S.-J, Woo, J.-R, Seo, E.J, Yu, M.-H, Ryu, S.-E.
Deposit date:2000-12-12
Release date:2001-03-14
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops.
J.Mol.Biol., 306, 2001

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