1B3K

Plasminogen activator inhibitor-1

Summary for 1B3K

• Entry DOI: 10.2210/pdb1b3k/pdb
• Related: 1C5G
• Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1 (1 entity in total)
• Functional Keywords: serpin, pai-1, inhibitor, blood clotting
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P05121
• Total number of polymer chains: 4
• Total formula weight: 171128.09

Authors

Sharp, A.M.,Stein, P.E.,Pannu, N.S.,Read, R.J. (deposition date: 1998-12-11, release date: 1999-12-11, Last modification date: 2024-04-03)

Primary citation

Sharp, A.M.,Stein, P.E.,Pannu, N.S.,Carrell, R.W.,Berkenpas, M.B.,Ginsburg, D.,Lawrence, D.A.,Read, R.J.
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.
Structure Fold.Des., 7:111-118, 1999

PubMed Abstract: Plasminogen activator inhibitor 1 (PAI-1) is a serpin that has a key role in the control of fibrinolysis through proteinase inhibition. PAI-1 also has a role in regulating cell adhesion processes relevant to tissue remodeling and metastasis; this role is mediated by its binding to the adhesive glycoprotein vitronectin rather than by proteinase inhibition. Active PAI-1 is metastable and spontaneously transforms to an inactive latent conformation. Previous attempts to crystallize the active conformation of PAI-1 have failed.

PubMed: 10368279
DOI: 10.1016/S0969-2126(99)80018-5

Experimental method

X-RAY DIFFRACTION (2.99 Å)