1BY7

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2. LOOP (66-98) DELETION MUTANT

Summary for 1BY7

• Entry DOI: 10.2210/pdb1by7/pdb
• Descriptor: PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-2) (2 entities in total)
• Functional Keywords: serpin, protein binding
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P05120
• Total number of polymer chains: 1
• Total formula weight: 43045.02

Authors

Harrop, S.J.,King, G.C.,Mabbutt, B.C.,Curmi, P.M.G. (deposition date: 1998-10-27, release date: 1999-10-24, Last modification date: 2024-11-13)

Primary citation

Harrop, S.J.,Jankova, L.,Coles, M.,Jardine, D.,Whittaker, J.S.,Gould, A.R.,Meister, A.,King, G.C.,Mabbutt, B.C.,Curmi, P.M.
The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
Structure Fold.Des., 7:43-54, 1999

PubMed Abstract: Plasminogen activator inhibitor 2 (PAI-2) is a member of the serpin family of protease inhibitors that function via a dramatic structural change from a native, stressed state to a relaxed form. This transition is mediated by a segment of the serpin termed the reactive centre loop (RCL); the RCL is cleaved on interaction with the protease and becomes inserted into betasheet A of the serpin. Major questions remain as to what factors facilitate this transition and how they relate to protease inhibition.

PubMed: 10368272
DOI: 10.1016/S0969-2126(99)80008-2

Experimental method

X-RAY DIFFRACTION (2 Å)