1F0C

STRUCTURE OF THE VIRAL SERPIN CRMA

Summary for 1F0C

• Entry DOI: 10.2210/pdb1f0c/pdb
• Descriptor: ICE INHIBITOR, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: apoptosis, caspase inhibitor, protease inhibitor, serpin, viral protein
• Biological source: Cowpox virus; More
• Cellular location: Host cytoplasm : P07385 P07385
• Total number of polymer chains: 2
• Total formula weight: 38282.36

Authors

Renatus, M.,Zhou, Q.,Stennicke, H.R.,Snipas, S.J.,Turk, D.,Bankston, L.A.,Liddington, R.C.,Salvesen, G.S. (deposition date: 2000-05-15, release date: 2000-09-06, Last modification date: 2024-02-07)

Primary citation

Renatus, M.,Zhou, Q.,Stennicke, H.R.,Snipas, S.J.,Turk, D.,Bankston, L.A.,Liddington, R.C.,Salvesen, G.S.
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold.Des., 8:789-797, 2000

PubMed Abstract: Cowpox virus expresses the serpin CrmA (cytokine response modifier A) in order to avoid inflammatory and apoptotic responses of infected host cells. The targets of CrmA are members of the caspase family of proteases that either initiate the extrinsic pathway of apoptosis (caspases 8 and 10) or trigger activation of the pro-inflammatory cytokines interleukin-1beta and interleukin-18 (caspase 1).

PubMed: 10903953
DOI: 10.1016/S0969-2126(00)00165-9

Experimental method

X-RAY DIFFRACTION (2.26 Å)