3A02
| Crystal structure of Aristaless homeodomain | Descriptor: | CADMIUM ION, CHLORIDE ION, Homeobox protein aristaless | Authors: | Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. | Deposit date: | 2009-02-28 | Release date: | 2010-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
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6RY3
| Structure of the WUS homeodomain | Descriptor: | ACETYL GROUP, Protein WUSCHEL, SULFATE ION | Authors: | Sloan, J.J, Wild, K, Sinning, I. | Deposit date: | 2019-06-10 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.374 Å) | Cite: | Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL. Nat Commun, 11, 2020
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5Z2S
| Crystal structure of DUX4-HD2 domain | Descriptor: | Double homeobox protein 4 | Authors: | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | Deposit date: | 2018-01-03 | Release date: | 2018-04-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of DUX4/IGH-driven transactivation. Leukemia, 32, 2018
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3A03
| Crystal structure of Hox11L1 homeodomain | Descriptor: | SODIUM ION, SULFATE ION, T-cell leukemia homeobox protein 2 | Authors: | Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. | Deposit date: | 2009-02-28 | Release date: | 2010-03-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
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6RYD
| WUS-HD bound to TGAA DNA | Descriptor: | DNA (5'-D(*AP*GP*TP*GP*TP*AP*TP*GP*AP*AP*TP*GP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*CP*AP*TP*TP*CP*AP*TP*AP*CP*AP*CP*T)-3'), MAGNESIUM ION, ... | Authors: | Sloan, J.J, Wild, K, Sinning, I. | Deposit date: | 2019-06-10 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.575 Å) | Cite: | Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL. Nat Commun, 11, 2020
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6A8R
| Crystal structure of DUX4 HD2 domain associated with ERG DNA binding site | Descriptor: | DNA (5'-D(P*AP*AP*TP*CP*TP*CP*AP*TP*CP*A)-3'), DNA (5'-D(P*TP*GP*AP*TP*GP*AP*GP*AP*TP*T)-3'), Double homeobox protein 4 | Authors: | Dong, X, Zhang, H, Cheng, N, Meng, G. | Deposit date: | 2018-07-10 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | DUX4HD2-DNAERGstructure reveals new insight into DUX4-Responsive-Element. Leukemia, 33, 2019
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6M3D
| X-ray crystal structure of tandemly connected engrailed homeodomains (EHD) with R53A mutations and DNA complex | Descriptor: | DNA (5'-D(*GP*GP*AP*TP*TP*AP*GP*GP*AP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*TP*CP*CP*TP*AP*AP*TP*CP*C)-3'), SODIUM ION, ... | Authors: | Sunami, T, Hirano, Y, Tamada, T, Kono, H. | Deposit date: | 2020-03-03 | Release date: | 2020-09-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for designing an array of engrailed homeodomains. Acta Crystallogr D Struct Biol, 76, 2020
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3RKQ
| NKX2.5 Homeodomain dimer bound to ANF-242 DNA | Descriptor: | ANF-242 DNA, Homeobox protein Nkx-2.5, MAGNESIUM ION | Authors: | Genis, C, Scone, P, Kasahara, H, Nam, H.-J. | Deposit date: | 2011-04-18 | Release date: | 2012-05-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51, 2012
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4RDU
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7XRC
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1E3O
| Crystal structure of Oct-1 POU dimer bound to MORE | Descriptor: | 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M. | Deposit date: | 2000-06-20 | Release date: | 2001-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
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5ZFZ
| Crystal structure of human DUX4 homeodomains bound to A12T DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*TP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*AP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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2HDD
| ENGRAILED HOMEODOMAIN Q50K VARIANT DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*C P*CP*GP*GP*A)-3'), PROTEIN (ENGRAILED HOMEODOMAIN Q50K) | Authors: | Tucker-Kellogg, L, Rould, M.A, Chambers, K.A, Ades, S.E, Sauer, R.T, Pabo, C.O. | Deposit date: | 1998-02-10 | Release date: | 1998-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity. Structure, 5, 1997
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2HOS
| Phage-Selected Homeodomain Bound to Unmodified DNA | Descriptor: | 3-METHYL-1,3-OXAZOLIDIN-2-ONE, 5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*CP*CP*GP*GP*A)-3', ... | Authors: | Shokat, K.M, Feldman, M.E, Simon, M.D. | Deposit date: | 2006-07-16 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and properties of a re-engineered homeodomain protein-DNA interface. Acs Chem.Biol., 1, 2006
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1PUF
| Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA | Descriptor: | 5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*CP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3', Homeobox protein Hox-A9, ... | Authors: | Laronde-Leblanc, N.A, Wolberger, C. | Deposit date: | 2003-06-24 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR Genes Dev., 17, 2003
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3CMY
| Structure of a homeodomain in complex with DNA | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*DAP*DCP*DAP*DTP*DAP*DAP*DP*DCP*DGP*DAP*DTP*DTP*DAP*DC)-3', 5'-D(*DTP*DGP*DTP*DAP*DAP*DTP*DCP*DGP*DAP*DTP*DTP*DAP*DTP*DG)-3', ... | Authors: | Birrane, G, Ladias, J.A.A, Soni, A. | Deposit date: | 2008-03-24 | Release date: | 2009-02-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Basis for DNA Recognition by the Human PAX3 Homeodomain. Biochemistry, 48, 2009
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8IK5
| Transcription factor LMX1a homeobox domain in complex with Wnt1 promoter | Descriptor: | DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), GLYCEROL, ... | Authors: | Lv, M.Q, Lin, L.Q. | Deposit date: | 2023-02-28 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.989 Å) | Cite: | Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
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7PSX
| Structure of HOXB13 bound to hydroxymethylated DNA | Descriptor: | DNA (5'-D(P*GP*GP*AP*CP*CP*TP*5HCP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13, ... | Authors: | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | Deposit date: | 2021-09-24 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of HOXB13 bound to hydroxymethylated DNA To Be Published
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1DU0
| ENGRAILED HOMEODOMAIN Q50A VARIANT DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*CP*CP*TP*AP*A)-3'), ENGRAILED HOMEODOMAIN | Authors: | Grant, R.A, Rould, M.A, Klemm, J.D, Pabo, C.O. | Deposit date: | 2000-01-13 | Release date: | 2000-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> ala) complex at 2.0 A. Biochemistry, 39, 2000
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1JGG
| Even-skipped Homeodomain Complexed to AT-rich DNA | Descriptor: | 5'-D(P*AP*AP*TP*TP*CP*AP*AP*TP*TP*A)-3', 5'-D(P*TP*AP*AP*TP*TP*GP*AP*AP*TP*T)-3', Segmentation Protein Even-Skipped | Authors: | Hirsch, J.A, Aggarwal, A.K. | Deposit date: | 2001-06-25 | Release date: | 2001-07-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity. EMBO J., 14, 1995
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1FJL
| HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE | Descriptor: | DNA (5'-D(*AP*AP*TP*AP*AP*TP*CP*TP*GP*AP*TP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*TP*CP*AP*GP*AP*TP*TP*AP*T)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*TP*CP*TP*GP*AP*TP*TP*AP*C)-3'), ... | Authors: | Wilson, D.S, Guenther, B, Desplan, C, Kuriyan, J. | Deposit date: | 1995-12-17 | Release date: | 1996-06-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell(Cambridge,Mass.), 82, 1995
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2D5V
| Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter | Descriptor: | 5'-D(*AP*TP*TP*AP*TP*TP*GP*AP*CP*TP*TP*AP*GP*A)-3', 5'-D(*TP*CP*TP*AP*AP*GP*TP*CP*AP*AP*TP*AP*AP*T)-3', ACETATE ION, ... | Authors: | Iyaguchi, D, Yao, M, Watanabe, N, Nishihira, J, Tanaka, I. | Deposit date: | 2005-11-07 | Release date: | 2006-12-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6 Structure, 15, 2007
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2XSD
| Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ... | Authors: | Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R. | Deposit date: | 2010-09-28 | Release date: | 2010-10-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA. Proteins, 79, 2011
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5JLW
| AntpHD with 15bp DNA duplex R-monothioated at Cytidine-8 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*GP*CP*(C7R)P*AP*TP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), ... | Authors: | White, M.A, Zandarashvili, L, Iwahara, J, Nguyen, D. | Deposit date: | 2016-04-27 | Release date: | 2016-06-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.088 Å) | Cite: | Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA Affinity. Chembiochem, 17, 2016
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1ENH
| STRUCTURAL STUDIES OF THE ENGRAILED HOMEODOMAIN | Descriptor: | ENGRAILED HOMEODOMAIN | Authors: | Clarke, N.D, Kissinger, C.R, Desjarlais, J, Gilliland, G.L, Pabo, C.O. | Deposit date: | 1994-05-20 | Release date: | 1994-08-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural studies of the engrailed homeodomain. Protein Sci., 3, 1994
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