6A8R

Crystal structure of DUX4 HD2 domain associated with ERG DNA binding site

Summary for 6A8R

• Entry DOI: 10.2210/pdb6a8r/pdb
• Descriptor: Double homeobox protein 4, DNA (5'-D(P*TP*GP*AP*TP*GP*AP*GP*AP*TP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*CP*AP*TP*CP*A)-3'), ... (4 entities in total)
• Functional Keywords: acute lymphoblastic leukemia, dux4/igh, erg binding site, tgat repeat, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 20450.09

Authors

Dong, X.,Zhang, H.,Cheng, N.,Meng, G. (deposition date: 2018-07-10, release date: 2018-10-24, Last modification date: 2023-11-22)

• Primary citation: Dong, X.,Zhang, H.,Cheng, N.,Li, K.,Meng, G.; DUX4HD2-DNAERGstructure reveals new insight into DUX4-Responsive-Element.; Leukemia, 33:550-553, 2019; PubMed: 30315230; DOI: 10.1038/s41375-018-0273-z

Experimental method

X-RAY DIFFRACTION (1.6 Å)